AKT1S1

AKT1 substrate 1 (proline-rich)
Identifiers
Symbols	AKT1S1 ; Lobe; PRAS40
External IDs	OMIM: 610221 MGI: 1914855 HomoloGene: 12162 ChEMBL: 1255161 GeneCards: AKT1S1 Gene
Gene ontology Molecular function • protein binding Cellular component • nucleoplasm • cytoplasm • cytosol • TORC1 complex Biological process • negative regulation of protein kinase activity • epidermal growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • negative regulation of TOR signaling • cellular response to heat • Fc-epsilon receptor signaling pathway • regulation of neuron apoptotic process • innate immune response • negative regulation of cell size • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • regulation of cellular response to heat Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84335	67605
Ensembl	ENSG00000204673	ENSMUSG00000011096
UniProt	Q96B36	Q9D1F4
RefSeq (mRNA)	NM_001098632	NM_001253920
RefSeq (protein)	NP_001092102	NP_001240849
Location (UCSC)	Chr 19: 49.87 – 49.88 Mb	Chr 7: 44.85 – 44.86 Mb
PubMed search

Proline-rich AKT1 substrate 1 (PRAS) is a protein that in humans is encoded by the AKT1S1 gene.^[1][2]

References

1. Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA (Mar 2003). "Identification of a proline-rich Akt substrate as a 14-3-3 binding partner". The Journal of Biological Chemistry 278 (12): 10189–94. doi:10.1074/jbc.M210837200. PMID 12524439.
2. "Entrez Gene: AKT1S1 AKT1 substrate 1 (proline-rich)".

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Saito A, Narasimhan P, Hayashi T, Okuno S, Ferrand-Drake M, Chan PH (Feb 2004). "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor". The Journal of Neuroscience 24 (7): 1584–93. doi:10.1523/JNEUROSCI.5209-03.2004. PMID 14973226.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
• Huang B, Porter G (Oct 2005). "Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis". Acta Pharmacologica Sinica 26 (10): 1253–8. doi:10.1111/j.1745-7254.2005.00184.x. PMID 16174443.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Vander Haar E, Lee SI, Bandhakavi S, Griffin TJ, Kim DH (Mar 2007). "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40". Nature Cell Biology 9 (3): 316–23. doi:10.1038/ncb1547. PMID 17277771.
• Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM (Mar 2007). "PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase". Molecular Cell 25 (6): 903–15. doi:10.1016/j.molcel.2007.03.003. PMID 17386266.
• Wang L, Harris TE, Roth RA, Lawrence JC (Jul 2007). "PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding". The Journal of Biological Chemistry 282 (27): 20036–44. doi:10.1074/jbc.M702376200. PMID 17510057.
• Fonseca BD, Smith EM, Lee VH, MacKintosh C, Proud CG (Aug 2007). "PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex". The Journal of Biological Chemistry 282 (34): 24514–24. doi:10.1074/jbc.M704406200. PMID 17604271.