ALG11

ALG11, alpha-1,2-mannosyltransferase
Identifiers
Symbols	ALG11 ; CDG1P; GT8
External IDs	OMIM: 613666 MGI: 2142632 HomoloGene: 68893 GeneCards: ALG11 Gene
EC number	2.4.1.131
Gene ontology Molecular function • GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity Cellular component • endoplasmic reticulum membrane • membrane • integral component of membrane Biological process • dolichol-linked oligosaccharide biosynthetic process • protein N-linked glycosylation via asparagine • post-translational protein modification • cellular protein metabolic process • mannosylation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	440138	207958
Ensembl	ENSG00000253710	ENSMUSG00000063362
UniProt	Q2TAA5	Q3TZM9
RefSeq (mRNA)	NM_001004127	NM_001243161
RefSeq (protein)	NP_001004127	NP_001230090
Location (UCSC)	Chr 13: 52.01 – 52.03 Mb	Chr 8: 22.06 – 22.07 Mb
PubMed search

Asparagine-linked glycosylation protein 11 is an enzyme encoded by the ALG11 gene.^[1]

See also

• Congenital disorder of glycosylation

^[2]

^[3]

References

1. "Entrez Gene: asparagine-linked glycosylation 11".
2. Cipollo, JF; Trimble, RB; Chi, JH; Yan, Q; Dean, N (2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem 276: 24.
3. Gao, XD; Nishikawa, A; Dean, N. (Jun 2004). "Physical interactions between the Alg1, Alg2, and Alg11 mannosyltransferases of the endoplasmic reticulum. 2004". Glycobiology 14 (6): 559–70. doi:10.1093/glycob/cwh072. PMID 15044395.

Further reading

• Rohozinski J, Lamb DJ, Bishop CE (2006). "UTP14c is a recently acquired retrogene associated with spermatogenesis and fertility in man.". Biol. Reprod. 74 (4): 644–51. doi:10.1095/biolreprod.105.046698. PMID 16354793.
• Rind N, Schmeiser V, Thiel C; et al. (2010). "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip.". Hum. Mol. Genet. 19 (8): 1413–24. doi:10.1093/hmg/ddq016. PMID 20080937.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Cipollo JF, Trimble RB, Chi JH, Yan Q, Dean N (June 2001). "The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum". J. Biol. Chem. 276 (24): 21828–40. doi:10.1074/jbc.M010896200. PMID 11278778.