ALOX15B

Arachidonate 15-lipoxygenase, type B
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ALOX15B ; 15-LOX-2
External IDs OMIM: 603697 MGI: 1098228 HomoloGene: 886 IUPHAR: 1389 ChEMBL: 2457 GeneCards: ALOX15B Gene
EC number 1.13.11.33
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 247 11688
Ensembl ENSG00000179593 ENSMUSG00000020891
UniProt O15296 O35936
RefSeq (mRNA) NM_001039130 NM_009661
RefSeq (protein) NP_001034219 NP_033791
Location (UCSC) Chr 17:
8.04 – 8.05 Mb
Chr 11:
69.18 – 69.2 Mb
PubMed search

Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene.[1][2] ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, ALOX15 or 15-lipoxygenase-1.

Function

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and 12-lipoxygenase and 44% amino acid sequence identity to human 5-lipoxygenase.[1] 15-LOX-2 converts arachidonic acid almost exclusively to the S stereoisomer of 15-Hydroperoxyicosatetraenoic acid which is commonly reduced to the S stereoisomer 15-Hydroxyeicosatetraenoic acid by ubiquitous cellular peroxidases; it metabolizes linoleic acid less effectively, converting this fatty acid to the S stereoisomer of 13-hydroperoxyoctadecadienoic acid which is likewise rapidly reduced to the S stereoisomer of 13-Hydroxyoctadecadienoic acid.[1] The ALOX15B gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.[2]

See also

References

  1. 1 2 3 Brash AR, Boeglin WE, Chang MS (Jun 1997). "Discovery of a second 15S-lipoxygenase in humans". Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6148–52. doi:10.1073/pnas.94.12.6148. PMC 21017. PMID 9177185.
  2. 1 2 "Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B".

Further reading

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