AMICA1

Adhesion molecule, interacts with CXADR antigen 1
Identifiers
Symbols	AMICA1 ; AMICA; CREA7-1; CREA7-4; Gm638; JAML
External IDs	OMIM: 609770 MGI: 2685484 HomoloGene: 17708 GeneCards: AMICA1 Gene
Gene ontology Molecular function • integrin binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • bicellular tight junction • integral component of membrane Biological process • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • blood coagulation • neutrophil chemotaxis • monocyte extravasation • gamma-delta T cell activation • regulation of immune response • leukocyte migration • positive regulation of epithelial cell proliferation involved in wound healing • neutrophil extravasation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	120425	270152
Ensembl	ENSG00000160593	ENSMUSG00000048534
UniProt	Q86YT9	Q80UL9
RefSeq (mRNA)	NM_001098526	NM_001005421
RefSeq (protein)	NP_001091996	NP_001005421
Location (UCSC)	Chr 11: 118.19 – 118.23 Mb	Chr 9: 45.08 – 45.11 Mb
PubMed search

Junctional adhesion molecule-like is a protein that in humans is encoded by the AMICA1 gene.^[1][2]

References

1. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
2. "Entrez Gene: AMICA1 adhesion molecule, interacts with CXADR antigen 1".

Further reading

• Kimura K; Wakamatsu A; Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Zen K; Liu Y; McCall IC; et al. (2005). "Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils". Mol. Biol. Cell 16 (6): 2694–703. doi:10.1091/mbc.E05-01-0036. PMC 1142417. PMID 15800062.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Moog-Lutz C; Cavé-Riant F; Guibal FC; et al. (2004). "JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells". Blood 102 (9): 3371–8. doi:10.1182/blood-2002-11-3462. PMID 12869515.
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.