ANAPC11

Anaphase promoting complex subunit 11
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2MT5​, 4R2Y​
Identifiers
Symbols	ANAPC11 ; APC11; Apc11p; HSPC214
External IDs	OMIM: 614534 MGI: 1913406 HomoloGene: 41136 GeneCards: ANAPC11 Gene
Gene ontology Molecular function • ubiquitin-protein transferase activity • zinc ion binding • ubiquitin-ubiquitin ligase activity • ubiquitin protein ligase activity • cullin family protein binding Cellular component • nucleoplasm • anaphase-promoting complex • nucleolus • cytosol Biological process • mitotic cell cycle • mitotic nuclear division • mitotic spindle assembly checkpoint • protein ubiquitination • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • positive regulation of mitotic metaphase/anaphase transition • cell division • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • protein K11-linked ubiquitination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51529	66156
Ensembl	ENSG00000141552	ENSMUSG00000025135
UniProt	Q9NYG5	Q9CPX9
RefSeq (mRNA)	NM_001002244	NM_001038230
RefSeq (protein)	NP_001002244	NP_001033319
Location (UCSC)	Chr 17: 81.89 – 81.9 Mb	Chr 11: 120.6 – 120.61 Mb
PubMed search

Anaphase-promoting complex subunit 11 is an enzyme that in humans is encoded by the ANAPC11 gene.^[1][2]

Interactions

ANAPC11 has been shown to interact with ANAPC2^[3][4] and CDC27.^[1][5]

References

1. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Sep 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc Natl Acad Sci U S A 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
2. "Entrez Gene: ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast)".
3. Tang, Z; Li B; Bharadwaj R; Zhu H; Ozkan E; Hakala K; Deisenhofer J; Yu H (Dec 2001). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell (United States) 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. ISSN 1059-1524. PMC 60759. PMID 11739784.
4. Ohta, T; Michel J J; Schottelius A J; Xiong Y (Apr 1999). "ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity". Mol. Cell (UNITED STATES) 3 (4): 535–41. doi:10.1016/S1097-2765(00)80482-7. ISSN 1097-2765. PMID 10230407.
5. Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. (England) 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947.

Further reading

• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chang TS, Jeong W, Lee DY; et al. (2005). "The RING-H2-finger protein APC11 as a target of hydrogen peroxide.". Free Radic. Biol. Med. 37 (4): 521–30. doi:10.1016/j.freeradbiomed.2004.05.006. PMID 15256223.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Vodermaier HC, Gieffers C, Maurer-Stroh S; et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tang Z, Li B, Bharadwaj R; et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.". Mol. Biol. Cell 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC 60759. PMID 11739784.
• Chan AH, Lee SM, Chim SS; et al. (2001). "Molecular cloning and characterization of a RING-H2 finger protein, ANAPC11, the human homolog of yeast Apc11p.". J. Cell. Biochem. 83 (2): 249–58. doi:10.1002/jcb.1217. PMID 11573242.
• Zhang QH, Ye M, Wu XY; et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.