ANAPC7

Anaphase promoting complex subunit 7
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ANAPC7 ; APC7
External IDs OMIM: 606949 MGI: 1929711 HomoloGene: 10512 GeneCards: ANAPC7 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51434 56317
Ensembl ENSG00000196510 ENSMUSG00000029466
UniProt Q9UJX3 Q9WVM3
RefSeq (mRNA) NM_001137664 NM_019805
RefSeq (protein) NP_001131136 NP_062779
Location (UCSC) Chr 12:
110.37 – 110.4 Mb
Chr 5:
122.42 – 122.44 Mb
PubMed search

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[1] Multiple transcript variants encoding different isoforms have been found for this gene.

Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[1]

Interactions

ANAPC7 has been shown to interact with ANAPC1,[2][3] ANAPC4,[2] CDC27[2][4] and CDC20.[2][5]

References

  1. 1 2 "Entrez Gene: ANAPC7 anaphase promoting complex subunit 7".
  2. 1 2 3 4 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947.
  3. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  4. Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  5. Nilsson J, Yekezare M, Minshull J, Pines J (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.

Further reading

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