ANKRD15

KN motif and ankyrin repeat domains 1
Identifiers
Symbols	KANK1 ; ANKRD15; CPSQ2; KANK
External IDs	OMIM: 607704 MGI: 2147707 HomoloGene: 17706 GeneCards: KANK1 Gene
Gene ontology Molecular function • protein binding • beta-catenin binding Cellular component • nucleus • cytoplasm • ruffle membrane Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of neuron projection development • positive regulation of Wnt signaling pathway • negative regulation of cell migration • negative regulation of actin filament polymerization • negative regulation of Rho protein signal transduction • positive regulation of catenin import into nucleus • negative regulation of insulin receptor signaling pathway • positive regulation of wound healing • negative regulation of substrate adhesion-dependent cell spreading • negative regulation of ruffle assembly • regulation of establishment of cell polarity • negative regulation of lamellipodium morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23189	107351
Ensembl	ENSG00000107104	ENSMUSG00000032702
UniProt	Q14678	E9Q238
RefSeq (mRNA)	NM_001256876	NM_181404
RefSeq (protein)	NP_001243805	NP_852069
Location (UCSC)	Chr 9: 0.47 – 0.75 Mb	Chr 19: 25.24 – 25.43 Mb
PubMed search

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.^[1][2][3]

This gene encodes a protein containing four ankyrin repeat domains in its C-terminus. The suggested role for this protein is in tumorigenesis of renal cell carcinoma.

Two alternatively spliced transcript variants encoding different isoforms have been identified.^[3]

References

1. Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830.
2. Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
3. "Entrez Gene: ANKRD15 ankyrin repeat domain 15".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Roy BC, Aoyagi T, Sarkar S, et al. (2005). "Pathological characterization of Kank in renal cell carcinoma". Exp. Mol. Pathol. 78 (1): 41–8. doi:10.1016/j.yexmp.2004.08.012. PMID 15596059.
• Wang Y, Onishi Y, Kakinuma N, et al. (2005). "Alternative splicing of the human Kank gene produces two types of Kank protein". Biochem. Biophys. Res. Commun. 330 (4): 1247–53. doi:10.1016/j.bbrc.2005.03.106. PMID 15823577.
• Wang Y, Kakinuma N, Zhu Y, Kiyama R (2007). "Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin". J. Cell. Sci. 119 (Pt 19): 4002–10. doi:10.1242/jcs.03169. PMID 16968744.