ANKRD23
| Ankyrin repeat domain 23 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ANKRD23 ; DARP; MARP3 | ||||||||||||
| External IDs | OMIM: 610736 MGI: 1925571 HomoloGene: 14025 GeneCards: ANKRD23 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 200539 | 78321 | |||||||||||
| Ensembl | ENSG00000163126 | ENSMUSG00000067653 | |||||||||||
| UniProt | Q86SG2 | Q812A3 | |||||||||||
| RefSeq (mRNA) | NM_144994 | NM_153502 | |||||||||||
| RefSeq (protein) | NP_659431 | NP_705722 | |||||||||||
| Location (UCSC) |
Chr 2: 96.82 – 96.86 Mb |
Chr 1: 36.53 – 36.54 Mb | |||||||||||
| PubMed search | |||||||||||||
Ankyrin repeat domain-containing protein 23 is a protein that in humans is encoded by the ANKRD23 gene.[1][2]
This gene is a member of the muscle ankyrin repeat protein (MARP) family and encodes a protein with four tandem ankyrin-like repeats. The protein is localized to the nucleus, functioning as a transcriptional regulator. Expression of this protein is induced during recovery following starvation.[2]
Interactions
ANKRD23 has been shown to interact with Titin[3] and MYPN.[3]
References
- ↑ Ikeda K, Emoto N, Matsuo M, Yokoyama M (Feb 2003). "Molecular identification and characterization of a novel nuclear protein whose expression is up-regulated in insulin-resistant animals". J Biol Chem 278 (6): 3514–20. doi:10.1074/jbc.M204563200. PMID 12456686.
- 1 2 "Entrez Gene: ANKRD23 ankyrin repeat domain 23".
- 1 2 Miller, Melanie K; Bang Marie-Louise; Witt Christian C; Labeit Dietmar; Trombitas Charles; Watanabe Kaori; Granzier Henk; McElhinny Abigail S; Gregorio Carol C; Labeit Siegfried (Nov 2003). "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules". J. Mol. Biol. (England) 333 (5): 951–64. doi:10.1016/j.jmb.2003.09.012. ISSN 0022-2836. PMID 14583192.
Further reading
- Hillier LW; Graves TA; Fulton RS; et al. (2005), "Generation and annotation of the DNA sequences of human chromosomes 2 and 4", Nature 434 (7034): 724–31, doi:10.1038/nature03466, PMID 15815621
- Gerhard DS; Wagner L; Feingold EA; et al. (2004), "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)", Genome Res. 14 (10B): 2121–7, doi:10.1101/gr.2596504, PMC 528928, PMID 15489334
- Nagueh SF; Shah G; Wu Y; et al. (2005), "Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy", Circulation 110 (2): 155–62, doi:10.1161/01.CIR.0000135591.37759.AF, PMID 15238456
- Ota T; Suzuki Y; Nishikawa T; et al. (2004), "Complete sequencing and characterization of 21,243 full-length human cDNAs", Nat. Genet. 36 (1): 40–5, doi:10.1038/ng1285, PMID 14702039
- Miller MK; Bang ML; Witt CC; et al. (2003), "The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules", J. Mol. Biol. 333 (5): 951–64, doi:10.1016/j.jmb.2003.09.012, PMID 14583192
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003), "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences", Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903, doi:10.1073/pnas.242603899, PMC 139241, PMID 12477932
- Dias Neto E; Correa RG; Verjovski-Almeida S; et al. (2000), "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags", Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6, doi:10.1073/pnas.97.7.3491, PMC 16267, PMID 10737800
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