ANKRD27

Ankyrin repeat domain 27 (VPS9 domain)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4B93​, 4CYM​, 4CZ2​
Identifiers
Symbols	ANKRD27 ; PP12899; VARP
External IDs	MGI: 2444103 HomoloGene: 12956 GeneCards: ANKRD27 Gene
Gene ontology Molecular function • SNARE binding • guanyl-nucleotide exchange factor activity • GTPase activator activity • protein binding • Rab GTPase binding Cellular component • cytoplasm • lysosome • early endosome • late endosome • plasma membrane • membrane • transport vesicle • cytoplasmic vesicle membrane • melanosome • neuron projection • tubular endosome Biological process • protein transport • negative regulation of SNARE complex assembly • endosome to melanosome transport • positive regulation of GTPase activity • early endosome to late endosome transport • neuron projection morphogenesis • positive regulation of dendrite morphogenesis • retrograde transport, endosome to plasma membrane Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	84079	245886
Ensembl	ENSG00000105186	ENSMUSG00000034867
UniProt	Q96NW4	Q3UMR0
RefSeq (mRNA)	NM_032139	NM_145633
RefSeq (protein)	NP_115515	NP_663608
Location (UCSC)	Chr 19: 32.6 – 32.68 Mb	Chr 7: 35.59 – 35.64 Mb
PubMed search

Ankyrin repeat domain-containing protein 27 is a protein that in humans is encoded by the ANKRD27 gene.^[1][2][3]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. Zhang X, He X, Fu XY, Chang Z (Mar 2006). "Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics". J Cell Sci 119 (Pt 6): 1053–62. doi:10.1242/jcs.02810. PMID 16525121.
3. "Entrez Gene: ANKRD27 ankyrin repeat domain 27 (VPS9 domain)".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.