ANP32E

Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CAY​, 4NFT​
Identifiers
Symbols	ANP32E ; LANP-L; LANPL
External IDs	OMIM: 609611 MGI: 1913721 HomoloGene: 137403 GeneCards: ANP32E Gene
Gene ontology Molecular function • phosphatase inhibitor activity • histone binding Cellular component • Swr1 complex • nucleus • cytoplasmic membrane-bounded vesicle Biological process • negative regulation of catalytic activity • histone exchange Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	81611	66471
Ensembl	ENSG00000143401	ENSMUSG00000015749
UniProt	Q9BTT0	P97822
RefSeq (mRNA)	NM_001136478	NM_001253757
RefSeq (protein)	NP_001129950	NP_001240686
Location (UCSC)	Chr 1: 150.22 – 150.24 Mb	Chr 3: 95.93 – 95.95 Mb
PubMed search

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.^[1][2] The ANP32E gene is located on chromosome 1q22.^[1] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.^[3] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis^[4] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.^[5]

See also

• ANP32A, ANP32B, ANP32C, ANP32D

References

1. Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741.
2. "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
3. Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature 505 (7485): 648–53. doi:10.1038/nature12922. PMID 24463511.
4. Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440.
5. Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690.

Further reading

• Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.