ANTXR2

Anthrax toxin receptor 2
PDB rendering based on 1sht.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1SHT​, 1SHU​, 1T6B​, 1TZN​
Identifiers
Symbols	ANTXR2 ; CMG-2; CMG2; HFS; ISH; JHF
External IDs	OMIM: 608041 MGI: 1919164 HomoloGene: 43236 GeneCards: ANTXR2 Gene
Gene ontology Molecular function • receptor activity • protein binding • metal ion binding Cellular component • extracellular region • endoplasmic reticulum membrane • plasma membrane • external side of plasma membrane • endosome membrane • integral component of membrane Biological process • reproductive process • toxin transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	118429	71914
Ensembl	ENSG00000163297	ENSMUSG00000029338
UniProt	P58335	Q6DFX2
RefSeq (mRNA)	NM_001145794	NM_133738
RefSeq (protein)	NP_001139266	NP_598499
Location (UCSC)	Chr 4: 79.9 – 80.13 Mb	Chr 5: 97.88 – 98.03 Mb
PubMed search

Anthrax toxin receptor 2 is a protein that in humans is encoded by the ANTXR2 gene.^[1][2][3]

See also

• Anthrax toxin

References

1. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA, Davis GE (Oct 2001). "Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling". J Cell Sci 114 (Pt 15): 2755–73. PMID 11683410.
2. Scobie HM, Rainey GJ, Bradley KA, Young JA (Apr 2003). "Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor". Proc Natl Acad Sci U S A 100 (9): 5170–4. doi:10.1073/pnas.0431098100. PMC 154317. PMID 12700348.
3. "Entrez Gene: ANTXR2 anthrax toxin receptor 2".

Further reading

• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Abrami L, Liu S, Cosson P; et al. (2003). "Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process". J. Cell Biol. 160 (3): 321–8. doi:10.1083/jcb.200211018. PMC 2172673. PMID 12551953.
• Dowling O, Difeo A, Ramirez MC; et al. (2003). "Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile hyaline fibromatosis and infantile systemic hyalinosis". Am. J. Hum. Genet. 73 (4): 957–66. doi:10.1086/378781. PMC 1180616. PMID 12973667.
• Hanks S, Adams S, Douglas J; et al. (2003). "Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis". Am. J. Hum. Genet. 73 (4): 791–800. doi:10.1086/378418. PMC 1180602. PMID 14508707.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wigelsworth DJ, Krantz BA, Christensen KA; et al. (2004). "Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen". J. Biol. Chem. 279 (22): 23349–56. doi:10.1074/jbc.M401292200. PMID 15044490.
• Lacy DB, Wigelsworth DJ, Scobie HM; et al. (2004). "Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor". Proc. Natl. Acad. Sci. U.S.A. 101 (17): 6367–72. doi:10.1073/pnas.0401506101. PMC 404051. PMID 15079089.
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Santelli E, Bankston LA, Leppla SH, Liddington RC (2004). "Crystal structure of a complex between anthrax toxin and its host cell receptor". Nature 430 (7002): 905–8. doi:10.1038/nature02763. PMID 15243628.
• Lacy DB, Wigelsworth DJ, Melnyk RA; et al. (2004). "Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation". Proc. Natl. Acad. Sci. U.S.A. 101 (36): 13147–51. doi:10.1073/pnas.0405405101. PMC 516539. PMID 15326297.
• Abrami L, Lindsay M, Parton RG; et al. (2004). "Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway". J. Cell Biol. 166 (5): 645–51. doi:10.1083/jcb.200312072. PMC 2172425. PMID 15337774.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lee JY, Tsai YM, Chao SC, Tu YF (2005). "Capillary morphogenesis gene-2 mutation in infantile systemic hyalinosis: ultrastructural study and mutation analysis in a Taiwanese infant". Clin. Exp. Dermatol. 30 (2): 176–9. doi:10.1111/j.1365-2230.2004.01698.x. PMID 15725249.
• Abrami L, Leppla SH, van der Goot FG (2006). "Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis". J. Cell Biol. 172 (2): 309–20. doi:10.1083/jcb.200507067. PMC 2063559. PMID 16401723.
• Gao M, Schulten K (2007). "Onset of anthrax toxin pore formation". Biophys. J. 90 (9): 3267–79. doi:10.1529/biophysj.105.079376. PMC 1432108. PMID 16473908.
• Wei W, Lu Q, Chaudry GJ; et al. (2006). "The LDL receptor-related protein LRP6 mediates internalization and lethality of anthrax toxin". Cell 124 (6): 1141–54. doi:10.1016/j.cell.2005.12.045. PMID 16564009.