ANXA11

Annexin A11
Identifiers
Symbols	ANXA11 ; ANX11; CAP50
External IDs	OMIM: 602572 MGI: 108481 HomoloGene: 22759 GeneCards: ANXA11 Gene
Gene ontology Molecular function • calcium ion binding • protein binding • calcium-dependent phospholipid binding • phosphatidylethanolamine binding • MHC class II protein complex binding • S100 protein binding • poly(A) RNA binding • calcium-dependent protein binding Cellular component • nuclear envelope • nucleoplasm • cytoplasm • spindle • membrane • midbody • melanosome • specific granule • azurophil granule • phagocytic vesicle • extracellular exosome Biological process • phagocytosis • cell cycle • cell division • response to calcium ion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	311	11744
Ensembl	ENSG00000122359	ENSMUSG00000021866
UniProt	P50995	P97384
RefSeq (mRNA)	NM_001157	NM_013469
RefSeq (protein)	NP_001148	NP_038497
Location (UCSC)	Chr 10: 80.15 – 80.21 Mb	Chr 14: 25.84 – 25.89 Mb
PubMed search

Annexin A11 is a protein that in humans is encoded by the ANXA11 gene.^[1][2][3]

Function

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.^[3]

Interactions

ANXA11 has been shown to interact with PDCD6^[4] and ALG2.^[5]

Clinical significance

It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in schizophrenia and contribute to pathomechanisms of this disorder.^[6]

References

1. Misaki Y, Pruijn GJ, van der Kemp AW, van Venrooij WJ (Feb 1994). "The 56K autoantigen is identical to human annexin XI". The Journal of Biological Chemistry 269 (6): 4240–6. PMID 7508441.
2. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID 9503022.
3. "Entrez Gene: ANXA11 annexin A11".
4. Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID 11883939.
5. Satoh H, Nakano Y, Shibata H, Maki M (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta 1600 (1-2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID 12445460.
6. Ghazaryan H (Jul 2013). "Annexin 11 expression pattern in schizophrenia". Electronic Journal of Natural Sciences 21 (2): 74–76.

Further reading

• Minami H, Tokumitsu H, Mizutani A, Watanabe Y, Watanabe M, Hidaka H (Jul 1992). "Specific binding of CAP-50 to calcyclin". FEBS Letters 305 (3): 217–9. doi:10.1016/0014-5793(92)80671-3. PMID 1299619.
• Dawson SJ, White LA (May 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Sjölin C, Dahlgren C (Jun 1996). "Isolation by calcium-dependent translation to neutrophil-specific granules of a 42-kD cytosolic protein, identified as being a fragment of annexin XI". Blood 87 (11): 4817–23. PMID 8639854.
• Brownawell AM, Creutz CE (Aug 1997). "Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII)". The Journal of Biological Chemistry 272 (35): 22182–90. doi:10.1074/jbc.272.35.22182. PMID 9268363.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Sudo T, Hidaka H (Feb 1999). "Characterization of the calcyclin (S100A6) binding site of annexin XI-A by site-directed mutagenesis". FEBS Letters 444 (1): 11–4. doi:10.1016/S0014-5793(99)00014-9. PMID 10037139.
• Bances P, Fernandez MR, Rodriguez-Garcia MI, Morgan RO, Fernandez MP (Oct 2000). "Annexin A11 (ANXA11) gene structure as the progenitor of paralogous annexins and source of orthologous cDNA isoforms". Genomics 69 (1): 95–103. doi:10.1006/geno.2000.6309. PMID 11013079.
• Satoh H, Shibata H, Nakano Y, Kitaura Y, Maki M (Mar 2002). "ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner". Biochemical and Biophysical Research Communications 291 (5): 1166–72. doi:10.1006/bbrc.2002.6600. PMID 11883939.
• Satoh H, Nakano Y, Shibata H, Maki M (Nov 2002). "The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner". Biochimica et Biophysica Acta 1600 (1-2): 61–7. doi:10.1016/S1570-9639(02)00445-4. PMID 12445460.
• Breen EC, Tang K (Mar 2003). "Calcyclin (S100A6) regulates pulmonary fibroblast proliferation, morphology, and cytoskeletal organization in vitro". Journal of Cellular Biochemistry 88 (4): 848–54. doi:10.1002/jcb.10398. PMID 12577318.
• Tomas A, Moss SE (May 2003). "Calcium- and cell cycle-dependent association of annexin 11 with the nuclear envelope". The Journal of Biological Chemistry 278 (22): 20210–6. doi:10.1074/jbc.M212669200. PMID 12601007.
• Farnaes L, Ditzel HJ (Aug 2003). "Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display". The Journal of Biological Chemistry 278 (35): 33120–6. doi:10.1074/jbc.M210852200. PMID 12805373.
• Tomas A, Futter C, Moss SE (Jun 2004). "Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis". The Journal of Cell Biology 165 (6): 813–22. doi:10.1083/jcb.200311054. PMC 2172404. PMID 15197175.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.