ANXA13

Annexin A13
Identifiers
Symbols	ANXA13 ; ANX13; ISA
External IDs	OMIM: 602573 MGI: 1917037 HomoloGene: 20908 GeneCards: ANXA13 Gene
Gene ontology Molecular function • calcium ion binding • calcium-dependent phospholipid binding Cellular component • plasma membrane Biological process • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	312	69787
Ensembl	ENSG00000104537	n/a
UniProt	P27216	Q99JG3
RefSeq (mRNA)	NM_001003954	NM_027211
RefSeq (protein)	NP_001003954	NP_081487
Location (UCSC)	Chr 8: 124.69 – 124.75 Mb	n/a
PubMed search

Annexin A13 is a protein that in humans is encoded by the ANXA13 gene.^[1][2]

Function

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membranes of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

References

1. Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1998). "Genomic locations of ANX11 and ANX13 and the evolutionary genetics of human annexins". Genomics 48 (1): 100–10. doi:10.1006/geno.1997.5148. PMID 9503022.
2. "Entrez Gene: ANXA13 annexin A13".

Further reading

• Wice BM, Gordon JI (Jan 1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". The Journal of Cell Biology 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC 2289284. PMID 1530946.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (Mar 2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Plant PJ, Lafont F, Lecat S, Verkade P, Simons K, Rotin D (Jun 2000). "Apical membrane targeting of Nedd4 is mediated by an association of its C2 domain with annexin XIIIb". The Journal of Cell Biology 149 (7): 1473–84. doi:10.1083/jcb.149.7.1473. PMC 2175132. PMID 10871286.
• Noda Y, Okada Y, Saito N, Setou M, Xu Y, Zhang Z, Hirokawa N (Oct 2001). "KIFC3, a microtubule minus end-directed motor for the apical transport of annexin XIIIb-associated Triton-insoluble membranes". The Journal of Cell Biology 155 (1): 77–88. doi:10.1083/jcb.200108042. PMC 2150803. PMID 11581287.
• Iglesias JM, Morgan RO, Jenkins NA, Copeland NG, Gilbert DJ, Fernandez MP (May 2002). "Comparative genetics and evolution of annexin A13 as the founder gene of vertebrate annexins". Molecular Biology and Evolution 19 (5): 608–18. doi:10.1093/oxfordjournals.molbev.a004120. PMID 11961095.
• Anderson NL, Polanski M, Pieper R, Gatlin T, Tirumalai RS, Conrads TP, Veenstra TD, Adkins JN, Pounds JG, Fagan R, Lobley A (Apr 2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Molecular & Cellular Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.