ANXA4

Annexin A4
PDB rendering based on 1ann.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2ZOC​
Identifiers
Symbols	ANXA4 ; ANX4; HEL-S-274; PIG28; ZAP36
External IDs	OMIM: 106491 MGI: 88030 HomoloGene: 68164 GeneCards: ANXA4 Gene
Gene ontology Molecular function • phospholipase inhibitor activity • calcium ion binding • calcium-dependent phospholipid binding • identical protein binding • calcium-dependent protein binding • NF-kappaB binding Cellular component • nucleus • cytoplasm • plasma membrane • cell surface • vesicle membrane • nuclear membrane • perinuclear region of cytoplasm • extracellular exosome Biological process • regulation of transcription from RNA polymerase II promoter • signal transduction • epithelial cell differentiation • negative regulation of NF-kappaB transcription factor activity • negative regulation of apoptotic process • negative regulation of catalytic activity • negative regulation of interleukin-8 secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	307	11746
Ensembl	ENSG00000196975	ENSMUSG00000029994
UniProt	P09525	P97429
RefSeq (mRNA)	NM_001153	NM_013471
RefSeq (protein)	NP_001144	NP_038499
Location (UCSC)	Chr 2: 69.64 – 69.83 Mb	Chr 6: 86.74 – 86.79 Mb
PubMed search

Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.^[1][2]

Function

Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.^[2]

References

1. Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.
2. "Entrez Gene: ANXA4 annexin A4".

Further reading

• Römisch J, Heimburger N (May 1990). "Purification and characterization of six annexins from human placenta". Biological Chemistry Hoppe-Seyler 371 (5): 383–8. doi:10.1515/bchm3.1990.371.1.383. PMID 2143074.
• Römisch J, Grote M, Weithmann KU, Heimburger N, Amann E (Nov 1990). "Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins". The Biochemical Journal 272 (1): 223–9. PMC 1149680. PMID 2148260.
• Freemont PS, Driessen HP, Verbi W, Crumpton MJ (Nov 1990). "Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV". Journal of Molecular Biology 216 (2): 219–21. doi:10.1016/S0022-2836(05)80310-9. PMID 2254922.
• Hauptmann R, Maurer-Fogy I, Krystek E, Bodo G, Andree H, Reutelingsperger CP (Oct 1989). "Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha". European Journal of Biochemistry / FEBS 185 (1): 63–71. doi:10.1111/j.1432-1033.1989.tb15082.x. PMID 2530088.
• Grundmann U, Amann E, Abel KJ, Küpper HA (Apr 1988). "Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family". Behring Institute Mitteilungen (82): 59–67. PMID 2970257.
• Ahn NG, Teller DC, Bienkowski MJ, McMullen BA, Lipkin EW, de Haën C (Dec 1988). "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor". The Journal of Biological Chemistry 263 (35): 18657–63. PMID 2974032.
• Tait JF, Sakata M, McMullen BA, Miao CH, Funakoshi T, Hendrickson LE, Fujikawa K (Aug 1988). "Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family". Biochemistry 27 (17): 6268–76. doi:10.1021/bi00417a011. PMID 2975506.
• Sjölin C, Stendahl O, Dahlgren C (Jun 1994). "Calcium-induced translocation of annexins to subcellular organelles of human neutrophils". The Biochemical Journal. 300 ( Pt 2) (Pt 2): 325–30. PMC 1138165. PMID 8002935.
• Kojima K, Yamamoto K, Irimura T, Osawa T, Ogawa H, Matsumoto I (Mar 1996). "Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids". The Journal of Biological Chemistry 271 (13): 7679–85. doi:10.1074/jbc.271.13.7679. PMID 8631806.
• Davis AJ, Butt JT, Walker JH, Moss SE, Gawler DJ (Oct 1996). "The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP". The Journal of Biological Chemistry 271 (40): 24333–6. doi:10.1074/jbc.271.40.24333. PMID 8798684.
• Satoh A, Takayama E, Kojima K, Ogawa H, Yamori T, Sato S, Kawaguchi T, Tsuruo T, Katsura Y, Kina T, Matsumoto I (Feb 1996). "Expression of carbohydrate-binding protein p33/41 in human tumor cell lines". Journal of Biochemistry 119 (2): 346–53. doi:10.1093/oxfordjournals.jbchem.a021246. PMID 8882729.
• Satoh A, Takayama E, Kojima K, Ogawa H, Katsura Y, Kina T, Matsumoto I (Mar 1997). "Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17". Biological & Pharmaceutical Bulletin 20 (3): 224–9. doi:10.1248/bpb.20.224. PMID 9084877.
• Dreier R, Schmid KW, Gerke V, Riehemann K (Aug 1998). "Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study". Histochemistry and Cell Biology 110 (2): 137–48. doi:10.1007/s004180050275. PMID 9720986.
• Chow A, Davis AJ, Gawler DJ (Mar 2000). "Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain". FEBS Letters 469 (1): 88–92. doi:10.1016/S0014-5793(00)01252-7. PMID 10708762.
• Han EK, Tahir SK, Cherian SP, Collins N, Ng SC (Jul 2000). "Modulation of paclitaxel resistance by annexin IV in human cancer cell lines". British Journal of Cancer 83 (1): 83–8. doi:10.1054/bjoc.2000.1311. PMC 2374538. PMID 10883672.
• Radau B, Otto A, Müller EC, Westermann P (Jul 2000). "Protein kinase C alpha-dependent phosphorylation of Golgi proteins". Electrophoresis 21 (13): 2684–7. doi:10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G. PMID 10949146.
• Gerner C, Frohwein U, Gotzmann J, Bayer E, Gelbmann D, Bursch W, Schulte-Hermann R (Dec 2000). "The Fas-induced apoptosis analyzed by high throughput proteome analysis". The Journal of Biological Chemistry 275 (50): 39018–26. doi:10.1074/jbc.M006495200. PMID 10978337.
• Tsujii-Hayashi Y, Kitahara M, Yamagaki T, Kojima-Aikawa K, Matsumoto I (Dec 2002). "A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes". The Journal of Biological Chemistry 277 (49): 47493–9. doi:10.1074/jbc.M206572200. PMID 12324456.