Diamine oxidase

Diamine oxidase, also known as histaminase, is an enzyme (EC 1.4.3.22) involved in the metabolism, oxidation, and inactivation of histamine in animals. Highest content is observed in the digestive tract and placenta.^[2]

References

↑ PDB: 3HI7; McGrath AP, Hilmer KM, Collyer CA, Shepard EM, Elmore BO, Brown DE, Dooley DM, Guss JM (Oct 2009). "Structure and inhibition of human diamine oxidase". Biochemistry 48 (41): 9810–22. doi:10.1021/bi9014192. PMC 2791411. PMID 19764817. ; rendered with PyMOL
↑ Agúndez JA, Ayuso P, Cornejo-García JA, Blanca M, Torres MJ, Doña I, Salas M, Blanca-López N, Canto G, Rondon C, Campo P, Laguna JJ, Fernández J, Martínez C, García-Martín E (2012). "The diamine oxidase gene is associated with hypersensitivity response to non-steroidal anti-inflammatory drugs". PLOS ONE 7 (11): e47571. doi:10.1371/journal.pone.0047571. PMID 23152756.

External links

Amine Oxidase (Copper-Containing) at the US National Library of Medicine Medical Subject Headings (MeSH)

Enzymes involved in neutrotransmission

monoamine

histidine → histamine

anabolism:	Histidine decarboxylase

catabolism:	Histamine N-methyltransferase Diamine oxidase

tyrosine→dopamine→epinephrine

anabolism:	Tyrosine hydroxylase Aromatic L-amino acid decarboxylase Dopamine beta-hydroxylase Phenylethanolamine N-methyltransferase

catabolism:	Catechol-O-methyl transferase Monoamine oxidase

glutamate→GABA

anabolism:	Glutamate decarboxylase

catabolism:	4-aminobutyrate transaminase

tryptophan→serotonin→melatonin

arginine→NO

Nitric oxide synthase (NOS1, NOS2, NOS3)

choline→Acetylcholine

anabolism:	Choline acetyltransferase

catabolism:	Cholinesterase (Acetylcholinesterase, Butyrylcholinesterase)

CH-NH₂ oxidoreductases (EC 1.4) - primarily amino acid oxidoreductases

1.4.1: NAD/NADP acceptor	Glutamate dehydrogenase GLUD1 GLUD2 Glutamate synthase (NADPH)

1.4.3: oxygen acceptor	D-amino acid oxidase Amine oxidase (Copper-containing (Lysyl Diamine Primary-amine)) (Flavin-containing (Monoamine)))

1.4.4: disulfide acceptor	Glycine cleavage system

1.4.99: other acceptors	D-amino acid dehydrogenase Amine dehydrogenase

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