KDM1B

Lysine (K)-specific demethylase 1B
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4FWE, 4FWF, 4FWJ, 4GU0, 4GU1, 4GUR, 4GUS, 4GUT, 4GUU, 4HSU
Identifiers
Symbols	KDM1B ; AOF1; C6orf193; LSD2; bA204B7.3; dJ298J15.2
External IDs	OMIM: 613081 HomoloGene: 131158 GeneCards: KDM1B Gene
Gene ontology Molecular function • DNA binding • zinc ion binding • histone demethylase activity (H3-dimethyl-K4 specific) • histone demethylase activity (H3-monomethyl-K4 specific) • flavin adenine dinucleotide binding Cellular component • nucleus • nucleoplasm Biological process • chromatin organization • regulation of gene expression by genetic imprinting • transcription, DNA-templated • regulation of transcription, DNA-templated • multicellular organismal development • histone H3-K4 demethylation • DNA methylation involved in gamete generation • regulation of DNA methylation • oxidation-reduction process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	221656	n/a
Ensembl	ENSG00000165097	n/a
UniProt	Q8NB78	n/a
RefSeq (mRNA)	NM_153042	n/a
RefSeq (protein)	NP_694587	n/a
Location (UCSC)	Chr 6: 18.16 – 18.22 Mb	n/a
PubMed search		n/a

Lysine (K)-specific demethylase 1B is a protein that in humans is encoded by the KDM1B gene.^[1]

Function

Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function.^[1][2]

References

1. "Entrez Gene: Lysine (K)-specific demethylase 1B".
2. Karytinos A, Forneris F, Profumo A, Ciossani G, Battaglioli E, Binda C, Mattevi A (Jun 2009). "A novel mammalian flavin-dependent histone demethylase". The Journal of Biological Chemistry 284 (26): 17775–82. doi:10.1074/jbc.M109.003087. PMC 2719416. PMID 19407342.

Further reading

• Yu H, Mashtalir N, Daou S, Hammond-Martel I, Ross J, Sui G, Hart GW, Rauscher FJ, Drobetsky E, Milot E, Shi Y, Affar el B (Nov 2010). "The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression". Molecular and Cellular Biology 30 (21): 5071–85. doi:10.1128/MCB.00396-10. PMC 2953049. PMID 20805357.
• Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG (Jul 2010). "Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation". Molecular Cell 39 (2): 222–33. doi:10.1016/j.molcel.2010.07.008. PMC 3518444. PMID 20670891.
• Ciccone DN, Su H, Hevi S, Gay F, Lei H, Bajko J, Xu G, Li E, Chen T (Sep 2009). "KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints". Nature 461 (7262): 415–8. doi:10.1038/nature08315. PMID 19727073.
• Machida YJ, Machida Y, Vashisht AA, Wohlschlegel JA, Dutta A (Dec 2009). "The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1". The Journal of Biological Chemistry 284 (49): 34179–88. doi:10.1074/jbc.M109.046755. PMC 2797188. PMID 19815555.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.