AP1B1

Adaptor-related protein complex 1, beta 1 subunit
Rendering of AP1B1 from PDB 1w63​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4HMY​, 4P6Z​
Identifiers
Symbols	AP1B1 ; ADTB1; AP105A; BAM22; CLAPB2
External IDs	OMIM: 600157 MGI: 1096368 HomoloGene: 21972 GeneCards: AP1B1 Gene
Gene ontology Molecular function • transporter activity • protein binding • protein transporter activity • protein kinase binding Cellular component • Golgi membrane • lysosomal membrane • cytosol • clathrin adaptor complex • cytoplasmic vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane Biological process • intracellular protein transport • post-Golgi vesicle-mediated transport • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • regulation of defense response to virus by virus • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	162	11764
Ensembl	ENSG00000100280	ENSMUSG00000009090
UniProt	Q10567	O35643
RefSeq (mRNA)	NM_001127	NM_001243043
RefSeq (protein)	NP_001118	NP_001229972
Location (UCSC)	Chr 22: 29.33 – 29.42 Mb	Chr 11: 4.99 – 5.04 Mb
PubMed search

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.^[1][2][3]

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Two transcript variants encoding different isoforms have been found for this gene, and variants utilizing alternative polyadenylation signals exist.^[3]

Interactions

AP1B1 has been shown to interact with KIF13A^[4] and AP1G1.^[5][6][7]

References

1. Peyrard M, Fransson I, Xie YG, Han FY, Ruttledge MH, Swahn S, Collins JE, Dunham I, Collins VP, Dumanski JP (January 1995). "Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene". Hum Mol Genet 3 (8): 1393–9. doi:10.1093/hmg/3.8.1393. PMID 7987321.
2. Peyrard M, Pan HQ, Kedra D, Fransson I, Swahn S, Hartman K, Clifton SW, Roe BA, Dumanski JP (February 1997). "Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12". Genomics 36 (1): 112–7. doi:10.1006/geno.1996.0431. PMID 8812422.
3. "Entrez Gene: AP1B1 adaptor-related protein complex 1, beta 1 subunit".
4. Nakagawa, T; Setou M; Seog D; Ogasawara K; Dohmae N; Takio K; Hirokawa N (November 2000). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex". Cell (UNITED STATES) 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. ISSN 0092-8674. PMID 11106728.
5. Takatsu, H; Sakurai M; Shin H W; Murakami K; Nakayama K (September 1998). "Identification and characterization of novel clathrin adaptor-related proteins". J. Biol. Chem. (UNITED STATES) 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. ISSN 0021-9258. PMID 9733768.
6. Fölsch, H; Ohno H; Bonifacino J S; Mellman I (October 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell (UNITED STATES) 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. ISSN 0092-8674. PMID 10535737.
7. Page, L J; Robinson M S (November 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. (UNITED STATES) 131 (3): 619–30. doi:10.1083/jcb.131.3.619. ISSN 0021-9525. PMC 2120623. PMID 7593184.

Further reading

• Kirchhausen T (2000). "Clathrin.". Annu. Rev. Biochem. 69: 699–727. doi:10.1146/annurev.biochem.69.1.699. PMID 10966473.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef.". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC 1083955. PMID 11463741.
• Bénichou S, Benmerah A (2003). "[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway]". Med Sci (Paris) 19 (1): 100–6. doi:10.1051/medsci/2003191100. PMID 12836198.
• Lim DS, Kirsch DG, Canman CE; et al. (1998). "ATM binds to beta-adaptin in cytoplasmic vesicles.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10146–51. doi:10.1073/pnas.95.17.10146. PMC 21476. PMID 9707615.
• Takatsu H, Sakurai M, Shin HW; et al. (1998). "Identification and characterization of novel clathrin adaptor-related proteins.". J. Biol. Chem. 273 (38): 24693–700. doi:10.1074/jbc.273.38.24693. PMID 9733768.
• Craig HM, Pandori MW, Guatelli JC (1998). "Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11229–34. doi:10.1073/pnas.95.19.11229. PMC 21624. PMID 9736718.
• Bresnahan PA, Yonemoto W, Ferrell S; et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.". Curr. Biol. 8 (22): 1235–8. doi:10.1016/S0960-9822(07)00517-9. PMID 9811606.
• Greenberg M, DeTulleo L, Rapoport I; et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4.". Curr. Biol. 8 (22): 1239–42. doi:10.1016/S0960-9822(07)00518-0. PMID 9811611.
• Laporte SA, Oakley RH, Zhang J; et al. (1999). "The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3712–7. doi:10.1073/pnas.96.7.3712. PMC 22359. PMID 10097102.
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells.". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
• Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members.". J. Biol. Chem. 274 (53): 37538–43. doi:10.1074/jbc.274.53.37538. PMID 10608806.
• Lai MM, Luo HR, Burnett PE; et al. (2000). "The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis.". J. Biol. Chem. 275 (44): 34017–20. doi:10.1074/jbc.C000429200. PMID 10931822.
• Nakagawa T, Setou M, Seog D; et al. (2001). "A novel motor, KIF13A, transports mannose-6-phosphate receptor to plasma membrane through direct interaction with AP-1 complex.". Cell 103 (4): 569–81. doi:10.1016/S0092-8674(00)00161-6. PMID 11106728.
• Takatsu H, Futatsumori M, Yoshino K; et al. (2001). "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three-hybrid system.". Biochem. Biophys. Res. Commun. 284 (4): 1083–9. doi:10.1006/bbrc.2001.5081. PMID 11409905.
• Doray B, Kornfeld S (2001). "Gamma subunit of the AP-1 adaptor complex binds clathrin: implications for cooperative binding in coated vesicle assembly.". Mol. Biol. Cell 12 (7): 1925–35. doi:10.1091/mbc.12.7.1925. PMC 55640. PMID 11451993.
• Jardine H, MacNee W, Donaldson K, Rahman I (2002). "Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1.". J. Biol. Chem. 277 (24): 21158–66. doi:10.1074/jbc.M112145200. PMID 11912197.