AP1M2

Adaptor-related protein complex 1, mu 2 subunit
Identifiers
Symbols	AP1M2 ; AP1-mu2; HSMU1B; MU-1B; MU1B; mu2
External IDs	OMIM: 607309 MGI: 1336974 HomoloGene: 55906 GeneCards: AP1M2 Gene
Gene ontology Molecular function • protein binding Cellular component • Golgi membrane • lysosomal membrane • cytosol • clathrin adaptor complex • cytoplasmic vesicle membrane • clathrin-coated endocytic vesicle membrane • trans-Golgi network membrane • intracellular membrane-bounded organelle Biological process • protein targeting • post-Golgi vesicle-mediated transport • vesicle targeting • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • regulation of defense response to virus by virus • membrane organization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10053	11768
Ensembl	ENSG00000129354	ENSMUSG00000003309
UniProt	Q9Y6Q5	Q9WVP1
RefSeq (mRNA)	NM_001300887	NM_001110300
RefSeq (protein)	NP_001287816	NP_001103770
Location (UCSC)	Chr 19: 10.57 – 10.59 Mb	Chr 9: 21.3 – 21.31 Mb
PubMed search

AP-1 complex subunit mu-2 is a protein that in humans is encoded by the AP1M2 gene.^[1][2]

Function

This gene encodes a subunit of the heterotetrameric adaptor-related protein complex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals.^[2]

Interactions

AP1M2 has been shown to interact with AP2B1.^[3]

References

1. Ohno H, Tomemori T, Nakatsu F, Okazaki Y, Aguilar RC, Foelsch H, Mellman I, Saito T, Shirasawa T, Bonifacino JS (Apr 1999). "Mu1B, a novel adaptor medium chain expressed in polarized epithelial cells". FEBS Letters 449 (2-3): 215–20. doi:10.1016/S0014-5793(99)00432-9. PMID 10338135.
2. "Entrez Gene: AP1M2 adaptor-related protein complex 1, mu 2 subunit".
3. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Hirst J, Robinson MS (Aug 1998). "Clathrin and adaptors". Biochimica et Biophysica Acta 1404 (1-2): 173–93. doi:10.1016/S0167-4889(98)00056-1. PMID 9714795.
• Ohno H, Stewart J, Fournier MC, Bosshart H, Rhee I, Miyatake S, Saito T, Gallusser A, Kirchhausen T, Bonifacino JS (Sep 1995). "Interaction of tyrosine-based sorting signals with clathrin-associated proteins". Science 269 (5232): 1872–5. doi:10.1126/science.7569928. PMID 7569928.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Seaman MN, Sowerby PJ, Robinson MS (Oct 1996). "Cytosolic and membrane-associated proteins involved in the recruitment of AP-1 adaptors onto the trans-Golgi network". The Journal of Biological Chemistry 271 (41): 25446–51. doi:10.1074/jbc.271.41.25446. PMID 8810314.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Stephens DJ, Banting G (Nov 1998). "Specificity of interaction between adaptor-complex medium chains and the tyrosine-based sorting motifs of TGN38 and lgp120". The Biochemical Journal 335 (3): 567–72. doi:10.1042/bj3350567. PMC 1219817. PMID 9794796.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L, Delamarre L, Bouchaert I, Sonigo P, Dokhelar MC, Benarous R (Feb 1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins". Journal of Virology 73 (2): 1350–61. PMC 103959. PMID 9882340.
• Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells". Cell 99 (2): 189–98. doi:10.1016/S0092-8674(00)81650-5. PMID 10535737.
• Nakatsu F, Kadohira T, Gilbert DJ, Jenkins NA, Kakuta H, Copeland NG, Saito T, Ohno H (2000). "Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2)". Cytogenetics and Cell Genetics 87 (1-2): 53–8. doi:10.1159/000015391. PMID 10640811.
• Umeda A, Meyerholz A, Ungewickell E (May 2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation". European Journal of Cell Biology 79 (5): 336–42. doi:10.1078/S0171-9335(04)70037-0. PMID 10887964.
• Fölsch H, Pypaert M, Schu P, Mellman I (Feb 2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized epithelial cells". The Journal of Cell Biology 152 (3): 595–606. doi:10.1083/jcb.152.3.595. PMC 2195989. PMID 11157985.
• Wyss S, Berlioz-Torrent C, Boge M, Blot G, Höning S, Benarous R, Thali M (Mar 2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]". Journal of Virology 75 (6): 2982–92. doi:10.1128/JVI.75.6.2982-2992.2001. PMC 115924. PMID 11222723.
• Ohka S, Ohno H, Tohyama K, Nomoto A (Oct 2001). "Basolateral sorting of human poliovirus receptor alpha involves an interaction with the mu1B subunit of the clathrin adaptor complex in polarized epithelial cells". Biochemical and Biophysical Research Communications 287 (4): 941–8. doi:10.1006/bbrc.2001.5660. PMID 11573956.
• Korolchuk VI, Banting G (Jun 2002). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles". Traffic 3 (6): 428–39. doi:10.1034/j.1600-0854.2002.30606.x. PMID 12010461.
• Collins BM, McCoy AJ, Kent HM, Evans PR, Owen DJ (May 2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608.
• Sugimoto H, Sugahara M, Fölsch H, Koide Y, Nakatsu F, Tanaka N, Nishimura T, Furukawa M, Mullins C, Nakamura N, Mellman I, Ohno H (Jul 2002). "Differential recognition of tyrosine-based basolateral signals by AP-1B subunit mu1B in polarized epithelial cells". Molecular Biology of the Cell 13 (7): 2374–82. doi:10.1091/mbc.E01-10-0096. PMC 117320. PMID 12134076.

External links

• AP1M2 human gene location in the UCSC Genome Browser.
• AP1M2 human gene details in the UCSC Genome Browser.