AP2S1

Adaptor-related protein complex 2, sigma 1 subunit
PDB rendering based on 1gw5.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1gw5​
Identifiers
Symbols	AP2S1 ; AP17; CLAPS2; FBH3; FBHOk; HHC3
External IDs	OMIM: 602242 MGI: 2141861 HomoloGene: 3001 GeneCards: AP2S1 Gene
Gene ontology Molecular function • transporter activity • protein binding • protein transporter activity • clathrin adaptor activity Cellular component • cytosol • plasma membrane • AP-2 adaptor complex • endocytic vesicle membrane • clathrin-coated endocytic vesicle membrane Biological process • intracellular protein transport • epidermal growth factor receptor signaling pathway • synaptic transmission • axon guidance • viral process • antigen processing and presentation of exogenous peptide antigen via MHC class II • regulation of endocytosis • negative regulation of epidermal growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • ephrin receptor signaling pathway • clathrin coat assembly • regulation of defense response to virus by virus • clathrin-mediated endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1175	232910
Ensembl	ENSG00000042753	ENSMUSG00000008036
UniProt	P53680	P62743
RefSeq (mRNA)	NM_001301076	NM_198613
RefSeq (protein)	NP_001288005	NP_941015
Location (UCSC)	Chr 19: 46.84 – 46.85 Mb	Chr 7: 16.74 – 16.75 Mb
PubMed search

AP-2 complex subunit sigma is a protein that in humans is encoded by the AP2S1 gene.^[1][2][3]

One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.^[3]

References

1. Winterpacht A, Endele S, Enklaar T, Fuhry M, Zabel B (Mar 1997). "Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2→q13.3". Cytogenet Cell Genet 75 (2–3): 132–5. doi:10.1159/000134463. PMID 9040778.
2. Holzmann K, Poltl A, Sauermann G (Nov 1998). "A novel spliced transcript of human CLAPS2 encoding a protein alternative to clathrin adaptor protein AP17". Gene 220 (1–2): 39–44. doi:10.1016/S0378-1119(98)00406-5. PMID 9767099.
3. "Entrez Gene: AP2S1 adaptor-related protein complex 2, sigma 1 subunit".

Further reading

• Pearse BM, Smith CJ, Owen DJ (2000). "Clathrin coat construction in endocytosis". Curr. Opin. Struct. Biol. 10 (2): 220–8. doi:10.1016/S0959-440X(00)00071-3. PMID 10753805.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Byland R, Vance PJ, Hoxie JA, Marsh M (2007). "A Conserved Dileucine Motif Mediates Clathrin and AP-2–dependent Endocytosis of the HIV-1 Envelope Protein". Mol. Biol. Cell 18 (2): 414–25. doi:10.1091/mbc.E06-06-0535. PMC 1783771. PMID 17108326.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Batonick M, Favre M, Boge M; et al. (2006). "Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2". Virology 342 (2): 190–200. doi:10.1016/j.virol.2005.08.001. PMID 16139856.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Vendeville A, Rayne F, Bonhoure A; et al. (2005). "HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses". Mol. Biol. Cell 15 (5): 2347–60. doi:10.1091/mbc.E03-12-0921. PMC 404028. PMID 15020715.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins BM, McCoy AJ, Kent HM; et al. (2002). "Molecular architecture and functional model of the endocytic AP2 complex". Cell 109 (4): 523–35. doi:10.1016/S0092-8674(02)00735-3. PMID 12086608.
• Berlioz-Torrent C, Shacklett BL, Erdtmann L; et al. (1999). "Interactions of the Cytoplasmic Domains of Human and Simian Retroviral Transmembrane Proteins with Components of the Clathrin Adaptor Complexes Modulate Intracellular and Cell Surface Expression of Envelope Glycoproteins". J. Virol. 73 (2): 1350–61. PMC 103959. PMID 9882340.
• Page LJ, Robinson MS (1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". J. Cell Biol. 131 (3): 619–30. doi:10.1083/jcb.131.3.619. PMC 2120623. PMID 7593184.
• Kirchhausen T, Nathanson KL, Matsui W; et al. (1989). "Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 2612–6. doi:10.1073/pnas.86.8.2612. PMC 286967. PMID 2495531.
• Kirchhausen T, Davis AC, Frucht S; et al. (1991). "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast". J. Biol. Chem. 266 (17): 11153–7. PMID 2040623.