APBA2BP

N-terminal EF-hand calcium binding protein 3
Identifiers
Symbols	NECAB3 ; APBA2BP; EFCBP3; NIP1; STIP3; SYTIP2; XB51; dJ63M2.4; dJ63M2.5
External IDs	OMIM: 612478 MGI: 1861721 HomoloGene: 10992 GeneCards: NECAB3 Gene
Gene ontology Molecular function • calcium ion binding • protein binding Cellular component • Golgi cis cisterna • nucleus • cytoplasm • endoplasmic reticulum membrane Biological process • protein secretion • protein metabolic process • regulation of amyloid precursor protein biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	63941	56846
Ensembl	ENSG00000125967	ENSMUSG00000027489
UniProt	Q96P71	Q9D6J4
RefSeq (mRNA)	NM_031231	NM_021546
RefSeq (protein)	NP_112508	NP_067521
Location (UCSC)	Chr 20: 33.66 – 33.67 Mb	Chr 2: 154.54 – 154.56 Mb
PubMed search

N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.^[1][2]

The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.^[2]

References

1. Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). "Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein". J Biol Chem 275 (30): 23134–8. doi:10.1074/jbc.C000302200. PMID 10833507.
2. "Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein".

Further reading

• Büssow K, Cahill D, Nietfeld W; et al. (1998). "A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.". Nucleic Acids Res. 26 (21): 5007–8. doi:10.1093/nar/26.21.5007. PMC 147919. PMID 9776767.
• Sugita S, Südhof TC (2000). "Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.". Biochemistry 39 (11): 2940–9. doi:10.1021/bi9920984. PMID 10715114.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Sugita S, Ho A, Südhof TC (2002). "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.". Neuroscience 112 (1): 51–63. doi:10.1016/S0306-4522(02)00063-5. PMID 12044471.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sumioka A, Imoto S, Martins RN; et al. (2003). "XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.". Biochem. J. 374 (Pt 1): 261–8. doi:10.1042/BJ20030489. PMC 1223589. PMID 12780348.
• Yoo JC, Chang JR, Kim SH; et al. (2004). "NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.". Exp. Cell Res. 292 (2): 393–402. doi:10.1016/j.yexcr.2003.09.025. PMID 14697346.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.