APBB3

Amyloid beta (A4) precursor protein-binding, family B, member 3

Rendering based on PDB 2DYQ.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols APBB3 ; FE65L2; SRA
External IDs OMIM: 602711 MGI: 108404 HomoloGene: 21221 GeneCards: APBB3 Gene
Orthologs
Species Human Mouse
Entrez 10307 225372
Ensembl ENSG00000113108 ENSMUSG00000006050
UniProt O95704 Q8R1C9
RefSeq (mRNA) NM_006051 NM_146085
RefSeq (protein) NP_006042 NP_666197
Location (UCSC) Chr 5:
140.56 – 140.59 Mb
Chr 18:
36.67 – 36.68 Mb
PubMed search

Amyloid beta A4 precursor protein-binding family B member 3 is a protein that in humans is encoded by the APBB3 gene.[1][2]

The protein encoded by this gene is a member of the APBB protein family. It is found in the cytoplasm and binds to the intracellular domain of the Alzheimer's disease beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the internalization of APP. Multiple transcript variants encoding several different isoforms have been found for this gene.[2]

References

  1. Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M (Jan 1998). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled". J Biol Chem 272 (52): 32869–77. doi:10.1074/jbc.272.52.32869. PMID 9407065.
  2. 1 2 "Entrez Gene: APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3".

Further reading

External links


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