API5

Apoptosis inhibitor 5
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3U0R​, 3V6A​
Identifiers
Symbols	API5 ; AAC-11; AAC11
External IDs	OMIM: 609774 MGI: 1888993 HomoloGene: 4809 GeneCards: API5 Gene
Gene ontology Molecular function • protein binding • fibroblast growth factor binding • poly(A) RNA binding Cellular component • nucleus • nucleoplasm • spliceosomal complex • cytoplasm • membrane Biological process • apoptotic process • negative regulation of apoptotic process • negative regulation of fibroblast apoptotic process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8539	11800
Ensembl	ENSG00000166181	ENSMUSG00000027193
UniProt	Q9BZZ5	O35841
RefSeq (mRNA)	NM_001142930	NM_001305258
RefSeq (protein)	NP_001136402	NP_001292187
Location (UCSC)	Chr 11: 43.31 – 43.34 Mb	Chr 2: 94.41 – 94.44 Mb
PubMed search

The human gene API5 encodes the protein Apoptosis inhibitor 5.^[1][2]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

References

1. Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res 57 (18): 4063–9. PMID 9307294.
2. "Entrez Gene: API5 apoptosis inhibitor 5".

Further reading

• Gianfrancesco F, Esposito T, Ciccodicola A; et al. (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene.". Cytogenet. Cell Genet. 84 (3-4): 164–6. doi:10.1159/000015247. PMID 10393420.
• Kim JW, Cho HS, Kim JH; et al. (2000). "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis.". Lab. Invest. 80 (4): 587–94. doi:10.1038/labinvest.3780008. PMID 10780674.
• Van den Berghe L, Laurell H, Huez I; et al. (2001). "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2.". Mol. Endocrinol. 14 (11): 1709–24. doi:10.1210/me.14.11.1709. PMID 11075807.
• Sutherland HG, Mumford GK, Newton K; et al. (2001). "Large-scale identification of mammalian proteins localized to nuclear sub-compartments.". Hum. Mol. Genet. 10 (18): 1995–2011. doi:10.1093/hmg/10.18.1995. PMID 11555636.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Li Z, Hu CY, Mo BQ; et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng 22 (4): 380–4. PMID 12703993.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Morris EJ, Michaud WA, Ji JY; et al. (2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.". PLoS Genet. 2 (11): e196. doi:10.1371/journal.pgen.0020196. PMC 1636698. PMID 17112319.