APLP2

Amyloid beta (A4) precursor-like protein 2
Identifiers
Symbols	APLP2 ; APLP-2; APPH; APPL2; CDEBP
External IDs	OMIM: 104776 HomoloGene: 20396 GeneCards: APLP2 Gene
Gene ontology Molecular function • DNA binding • serine-type endopeptidase inhibitor activity • protein binding • heparin binding • identical protein binding • transition metal ion binding Cellular component • nucleus • plasma membrane • membrane • integral component of membrane • extracellular exosome Biological process • suckling behavior • cellular copper ion homeostasis • regulation of epidermal growth factor-activated receptor activity • G-protein coupled receptor signaling pathway • mating behavior • locomotory behavior • cholesterol metabolic process • negative regulation of endopeptidase activity • extracellular matrix organization • forebrain development • midbrain development • regulation of protein binding • neuromuscular process controlling balance Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	334	11804
Ensembl	ENSG00000084234	ENSMUSG00000031996
UniProt	Q06481	Q06335
RefSeq (mRNA)	NM_001142276	NM_001102455
RefSeq (protein)	NP_001135748	NP_001095925
Location (UCSC)	Chr 11: 130.07 – 130.14 Mb	Chr 9: 31.15 – 31.21 Mb
PubMed search

Amyloid-like protein 2, also known as APLP2, is a protein that in humans is encoded by the APLP2 gene.^[1][2] APLP2 along with APLP1 are important modulators of glucose and insulin homeostasis.^[3]

Function

APLP2 associates with antigen presentation molecules like MHC class I molecules and regulates their surface expression by enhancing endocytosis.^[4][5]

APLP1 and APLP2 double knockout mice display hypoglycemia and hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.^[3] APLP2 has also been shown to regulate development of the brain by regulating migration and differentiation of neural stem cells.^[6]

Interactions

APLP2 has been shown to interact with APBB1.^[7][8]

References

1. "Entrez Gene: APLP2 Amyloid beta (A4) precursor-like protein 2".
2. Leach R, Ko M, Krawetz SA (1999). "Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 87 (3-4): 215–6. doi:10.1159/000015472. PMID 10702673.
3. Needham BE, Wlodek ME, Ciccotosto GD, Fam BC, Masters CL, Proietto J, Andrikopoulos S, Cappai R (June 2008). "Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth". J. Pathol. 215 (2): 155–63. doi:10.1002/path.2343. PMID 18393365.
4. Tuli A, Sharma M, Naslavsky N, Caplan S, Solheim JC (June 2008). "Specificity of amyloid precursor-like protein 2 interactions with MHC class I molecules". Immunogenetics 60 (6): 303–13. doi:10.1007/s00251-008-0296-0. PMC 2683759. PMID 18452037.
5. Tuli A, Sharma M, McIlhaney MM, Talmadge JE, Naslavsky N, Caplan S, Solheim JC (August 2008). "Amyloid precursor-like protein 2 increases the endocytosis, instability, and turnover of the H2-K(d) MHC class I molecule". J. Immunol. 181 (3): 1978–87. doi:10.4049/jimmunol.181.3.1978. PMC 2607064. PMID 18641335.
6. Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B, Gärtner A (2013). "APLP2 regulates neuronal stem cell differentiation during cortical development". J. Cell. Sci. 126 (Pt 5): 1268–77. doi:10.1242/jcs.122440. PMID 23345401.
7. Guénette SY, Chen J, Jondro PD, Tanzi RE (October 1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
8. Tanahashi H, Tabira T (February 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969.

Further reading

• Blangy A, Vidal F, Cuzin F, Yang YH, Boulukos K, Rassoulzadegan M (1995). "CDEBP, a site-specific DNA-binding protein of the 'APP-like' family, is required during the early development of the mouse". J. Cell. Sci. 108 ( Pt 2) (2): 675–83. PMID 7539437.
• von der Kammer H, Hanes J, Klaudiny J, Scheit KH (1994). "A human amyloid precursor-like protein is highly homologous to a mouse sequence-specific DNA-binding protein". DNA Cell Biol. 13 (11): 1137–43. doi:10.1089/dna.1994.13.1137. PMID 7702756.
• Bush AI, Pettingell WH, de Paradis M, Tanzi RE, Wasco W (1994). "The amyloid beta-protein precursor and its mammalian homologues. Evidence for a zinc-modulated heparin-binding superfamily". J. Biol. Chem. 269 (43): 26618–21. PMID 7929392.
• von der Kammer H, Löffler C, Hanes J, Klaudiny J, Scheit KH, Hansmann I (1994). "The gene for the amyloid precursor-like protein APLP2 is assigned to human chromosome 11q23-q25". Genomics 20 (2): 308–11. doi:10.1006/geno.1994.1174. PMID 8020984.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE (1993). "Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor". Nat. Genet. 5 (1): 95–100. doi:10.1038/ng0993-95. PMID 8220435.
• Sprecher CA, Grant FJ, Grimm G, O'Hara PJ, Norris F, Norris K, Foster DC (1993). "Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family". Biochemistry 32 (17): 4481–6. doi:10.1021/bi00068a002. PMID 8485127.
• Guénette SY, Chen J, Jondro PD, Tanzi RE (1996). "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10832–7. doi:10.1073/pnas.93.20.10832. PMC 38241. PMID 8855266.
• Bressler SL, Gray MD, Sopher BL, Hu Q, Hearn MG, Pham DG, Dinulos MB, Fukuchi K, Sisodia SS, Miller MA, Disteche CM, Martin GM (1996). "cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein". Hum. Mol. Genet. 5 (10): 1589–98. doi:10.1093/hmg/5.10.1589. PMID 8894693.
• Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y (1997). "Phosphorylation of Alzheimer beta-amyloid precursor-like proteins". Biochemistry 36 (15): 4643–9. doi:10.1021/bi962618k. PMID 9109675.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Duilio A, Faraonio R, Minopoli G, Zambrano N, Russo T (1998). "Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein". Biochem. J. 330 ( Pt 1) (1): 513–9. PMC 1219167. PMID 9461550.
• Lyckman AW, Confaloni AM, Thinakaran G, Sisodia SS, Moya KL (1998). "Post-translational processing and turnover kinetics of presynaptically targeted amyloid precursor superfamily proteins in the central nervous system". J. Biol. Chem. 273 (18): 11100–6. doi:10.1074/jbc.273.18.11100. PMID 9556595.
• Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6. doi:10.1016/S0304-3940(98)00995-1. PMID 10081969.
• Homayouni R, Rice DS, Sheldon M, Curran T (1999). "Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1". J. Neurosci. 19 (17): 7507–15. PMID 10460257.
• Mitsuuchi Y, Johnson SW, Sonoda G, Tanno S, Golemis EA, Testa JR (1999). "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2". Oncogene 18 (35): 4891–8. doi:10.1038/sj.onc.1203080. PMID 10490823.
• Leach R, Ko M, Krawetz SA (1999). "Assignment of amyloid-precursor-like protein 2 gene (APLP2) to 11q24 by fluorescent in situ hybridization". Cytogenet. Cell Genet. 87 (3-4): 215–6. doi:10.1159/000015472. PMID 10702673.
• Xu KP, Zoukhri D, Zieske JD, Dartt DA, Sergheraert C, Loing E, Yu FS (2001). "A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells". Am. J. Physiol., Cell Physiol. 281 (2): C603–14. PMID 11443060.
• Yarden RI, Brody LC (2001). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10.1002/jcb.1257. PMID 11746496.
• Scheinfeld MH, Ghersi E, Laky K, Fowlkes BJ, D'Adamio L (2002). "Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription". J. Biol. Chem. 277 (46): 44195–201. doi:10.1074/jbc.M208110200. PMID 12228233.