APOF

Apolipoprotein F
Identifiers
Symbols	APOF ; Apo-F; LTIP
External IDs	OMIM: 107760 MGI: 104539 HomoloGene: 48030 GeneCards: APOF Gene
Gene ontology Molecular function • receptor binding • lipid transporter activity • cholesterol binding Cellular component • extracellular region • low-density lipoprotein particle • high-density lipoprotein particle Biological process • lipid metabolic process • lipid transport • cholesterol metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	319	103161
Ensembl	ENSG00000175336	ENSMUSG00000047631
UniProt	Q13790	Q91V80
RefSeq (mRNA)	NM_001638	NM_133997
RefSeq (protein)	NP_001629	NP_598758
Location (UCSC)	Chr 12: 56.36 – 56.36 Mb	Chr 10: 128.27 – 128.27 Mb
PubMed search

Apolipoprotein F
Identifiers
Symbol	APOF
Pfam	PF15148
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene.^[1][2]

The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.^[2]

References

1. Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
2. "Entrez Gene: APOF apolipoprotein F".

Further reading

• Morton RE, Gnizak HM, Greene DJ; et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kabbara A, Payet N, Cottel D; et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102.
• Anderson NL, Polanski M, Pieper R; et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell Proteomics 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
• Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
• Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.