APOL2

Apolipoprotein L, 2
Identifiers
Symbols	APOL2 ; APOL-II; APOL3
External IDs	OMIM: 607252 MGI: 2444921 HomoloGene: 12785 GeneCards: APOL2 Gene
Gene ontology Molecular function • receptor binding • high-density lipoprotein particle binding • lipid binding Cellular component • extracellular region • endoplasmic reticulum membrane • membrane Biological process • lipid metabolic process • lipid transport • acute-phase response • multicellular organismal development • cholesterol metabolic process • lipoprotein metabolic process • maternal process involved in female pregnancy Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23780	239552
Ensembl	ENSG00000128335	ENSMUSG00000056656
UniProt	Q9BQE5	A2VDH7
RefSeq (mRNA)	NM_030882	NM_001081970
RefSeq (protein)	NP_112092	NP_001075439
Location (UCSC)	Chr 22: 36.23 – 36.24 Mb	Chr 15: 77.75 – 77.76 Mb
PubMed search

Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.^[1][2][3]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene.^[3]

References

1. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP; et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
2. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
3. "Entrez Gene: APOL2 apolipoprotein L, 2".

Further reading

• McGhee KA, Morris DW, Schwaiger S (2005). "Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a novel DNA pooling strategy for public database SNPs". Schizophr. Res. 76 (2–3): 231–8. doi:10.1016/j.schres.2005.01.006. PMID 15949655.
• Gerhard DS, Wagner L, Feingold EA (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
• Duchateau PN, Pullinger CR, Cho MH (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
• Adams MD, Kerlavage AR, Fleischmann RD (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098.