APOL3

Apolipoprotein L, 3
Identifiers
Symbols	APOL3 ; APOLIII; CG121; CG12_1; apoL-III
External IDs	OMIM: 607253 MGI: 1923011 HomoloGene: 129701 GeneCards: APOL3 Gene
Gene ontology Molecular function • signal transducer activity • lipid transporter activity • lipid binding Cellular component • extracellular region • cytoplasm • membrane Biological process • lipid transport • inflammatory response • signal transduction • lipoprotein metabolic process • positive regulation of I-kappaB kinase/NF-kappaB signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80833	75761
Ensembl	ENSG00000128284	ENSMUSG00000010601
UniProt	O95236	B2RT54
RefSeq (mRNA)	NM_014349	NM_001164640
RefSeq (protein)	NP_055164	NP_001158112
Location (UCSC)	Chr 22: 36.14 – 36.17 Mb	Chr 15: 77.39 – 77.4 Mb
PubMed search

Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene.^[1][2]

This gene is a member of the apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. In addition, expression of this gene is upregulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Six transcript variants encoding three different isoforms have been found for this gene.^[2]

References

1. Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (May 2001). "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics 74 (1): 71–8. doi:10.1006/geno.2001.6534. PMID 11374903.
2. "Entrez Gene: APOL3 apolipoprotein L, 3".

Further reading

• Horrevoets AJ, Fontijn RD, van Zonneveld AJ, et al. (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood 93 (10): 3418–31. PMID 10233894.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
• Duchateau PN, Pullinger CR, Cho MH, et al. (2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. Lipid Res. 42 (4): 620–30. PMID 11290834.
• Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue". Genomics 79 (4): 539–46. doi:10.1006/geno.2002.6729. PMID 11944986.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.