APPBP2

Amyloid beta precursor protein (cytoplasmic tail) binding protein 2
Identifiers
Symbols	APPBP2 ; APP-BP2; HS.84084; PAT1
External IDs	OMIM: 605324 MGI: 1914134 HomoloGene: 31378 GeneCards: APPBP2 Gene
Gene ontology Molecular function • microtubule motor activity • protein binding Cellular component • nucleus • cytoplasm • microtubule • microtubule associated complex • cytoplasmic vesicle membrane Biological process • intracellular protein transport • intracellular transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10513	66884
Ensembl	ENSG00000062725	ENSMUSG00000018481
UniProt	Q92624	Q9DAX9
RefSeq (mRNA)	NM_001282476	NM_025825
RefSeq (protein)	NP_001269405	NP_080101
Location (UCSC)	Chr 17: 60.44 – 60.53 Mb	Chr 11: 85.19 – 85.24 Mb
PubMed search

Amyloid protein-binding protein 2 is a protein that in humans is encoded by the APPBP2 gene.^[1][2]

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. This gene has been found to be highly expressed in breast cancer. Multiple polyadenylation sites have been found for this gene.^[2]

Interactions

APPBP2 has been shown to interact with Amyloid precursor protein.^[1]{

References

1. Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Jan 1999). "PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein". Proc Natl Acad Sci U S A 95 (25): 14745–50. doi:10.1073/pnas.95.25.14745. PMC 24520. PMID 9843960.
2. "Entrez Gene: APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2".

Further reading

• Nagase T, Seki N, Ishikawa K; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Bärlund M, Monni O, Kononen J; et al. (2000). "Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.". Cancer Res. 60 (19): 5340–4. PMID 11034067.
• Monni O, Barlund M, Mousses S; et al. (2001). "Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer.". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5711–6. doi:10.1073/pnas.091582298. PMC 33278. PMID 11331760.
• Gao Y, Pimplikar SW (2002). "The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14979–84. doi:10.1073/pnas.261463298. PMC 64969. PMID 11742091.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Benboudjema L, Mulvey M, Gao Y; et al. (2003). "Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.". J. Virol. 77 (17): 9192–203. doi:10.1128/JVI.77.17.9192-9203.2003. PMC 187382. PMID 12915535.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.