ARFIP2

ADP-ribosylation factor interacting protein 2
PDB rendering based on 1i49.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1I49​, 1I4D​, 1I4L​, 1I4T​, 4DCN​
Identifiers
Symbols	ARFIP2 ; POR1
External IDs	OMIM: 601638 MGI: 1924182 HomoloGene: 8234 GeneCards: ARFIP2 Gene
Gene ontology Molecular function • protein binding • GTP binding • protein domain specific binding • GTP-dependent protein binding • Rac GTPase binding • phosphatidylinositol-4-phosphate binding Cellular component • ruffle • cytoplasm • plasma membrane • cell cortex • trans-Golgi network membrane Biological process • movement of cell or subcellular component • small GTPase mediated signal transduction • lamellipodium assembly • actin cytoskeleton organization • ruffle organization • regulation of Arp2/3 complex-mediated actin nucleation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23647	76932
Ensembl	ENSG00000132254	ENSMUSG00000030881
UniProt	P53365	Q8K221
RefSeq (mRNA)	NM_001242854	NM_029802
RefSeq (protein)	NP_001229783	NP_084078
Location (UCSC)	Chr 11: 6.47 – 6.48 Mb	Chr 7: 105.63 – 105.64 Mb
PubMed search

Arfaptin-2 is a protein that in humans is encoded by the ARFIP2 gene.^[1][2][3]

Interactions

ARFIP2 has been shown to interact with Arf6,^[4][5] ARF3,^[2] ARF5^[2][5] and RAC1.^[1]{^[5][6]

References

1. Van Aelst L, Joneson T, Bar-Sagi D (October 1996). "Identification of a novel Rac1-interacting protein involved in membrane ruffling". EMBO J 15 (15): 3778–86. PMC 452058. PMID 8670882.
2. Kanoh H, Williger BT, Exton JH (April 1997). "Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation factor, is recruited to Golgi membranes". J Biol Chem 272 (9): 5421–9. doi:10.1074/jbc.272.9.5421. PMID 9038142.
3. "Entrez Gene: ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2)".
4. D'Souza-Schorey, C; Boshans R L; McDonough M; Stahl P D; Van Aelst L (September 1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements". EMBO J. (ENGLAND) 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. ISSN 0261-4189. PMC 1170175. PMID 9312003.
5. Shin, O H; Exton J H (August 2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1". Biochem. Biophys. Res. Commun. (United States) 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. ISSN 0006-291X. PMID 11478794.
6. Tarricone, C; Xiao B; Justin N; Walker P A; Rittinger K; Gamblin S J; Smerdon S J (May 2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways". Nature (England) 411 (6834): 215–9. doi:10.1038/35075620. ISSN 0028-0836. PMID 11346801.

Further reading

• D'Souza-Schorey C, Boshans RL, McDonough M; et al. (1997). "A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements.". EMBO J. 16 (17): 5445–54. doi:10.1093/emboj/16.17.5445. PMC 1170175. PMID 9312003.
• Tarricone C, Xiao B, Justin N; et al. (2001). "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.". Nature 411 (6834): 215–9. doi:10.1038/35075620. PMID 11346801.
• Shin OH, Exton JH (2001). "Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors and Rac1.". Biochem. Biophys. Res. Commun. 285 (5): 1267–73. doi:10.1006/bbrc.2001.5330. PMID 11478794.
• Peters PJ, Ning K, Palacios F; et al. (2002). "Arfaptin 2 regulates the aggregation of mutant huntingtin protein.". Nat. Cell Biol. 4 (3): 240–5. doi:10.1038/ncb761. PMID 11854752.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lu L, Hong W (2004). "Interaction of Arl1-GTP with GRIP domains recruits autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi.". Mol. Biol. Cell 14 (9): 3767–81. doi:10.1091/mbc.E03-01-0864. PMC 196566. PMID 12972563.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rangone H, Pardo R, Colin E; et al. (2005). "Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.". J. Biol. Chem. 280 (23): 22021–8. doi:10.1074/jbc.M407528200. PMID 15809304.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.