ARFRP1

ADP-ribosylation factor related protein 1
Identifiers
Symbols ARFRP1 ; ARL18; ARP; Arp1
External IDs OMIM: 604699 MGI: 1923938 HomoloGene: 2425 GeneCards: ARFRP1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 10139 76688
Ensembl ENSG00000101246 ENSMUSG00000038671
UniProt Q13795 Q8BXL7
RefSeq (mRNA) NM_001134758 NM_001165991
RefSeq (protein) NP_001128230 NP_001159463
Location (UCSC) Chr 20:
63.7 – 63.71 Mb
Chr 2:
181.36 – 181.37 Mb
PubMed search

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.[1][2]

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.[2]

Interactions

ARFRP1 has been shown to interact with PSCD1.[3]

References

  1. Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.
  2. 1 2 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
  3. Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

Further reading

External links

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