ARHGAP24

Rho GTPase activating protein 24
Identifiers
Symbols	ARHGAP24 ; FILGAP; RC-GAP72; RCGAP72; p73; p73RhoGAP
External IDs	OMIM: 610586 MGI: 1922647 HomoloGene: 32754 GeneCards: ARHGAP24 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding Cellular component • cytosol • cytoskeleton • focal adhesion • cell projection Biological process • angiogenesis • small GTPase mediated signal transduction • cell differentiation • negative regulation of Rac protein signal transduction • wound healing, spreading of epidermal cells • regulation of small GTPase mediated signal transduction • activation of GTPase activity • negative regulation of ruffle assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	83478	231532
Ensembl	ENSG00000138639	ENSMUSG00000057315
UniProt	Q8N264	Q8C4V1
RefSeq (mRNA)	NM_001025616	NM_001286468
RefSeq (protein)	NP_001020787	NP_001273397
Location (UCSC)	Chr 4: 85.48 – 86 Mb	Chr 5: 102.48 – 102.9 Mb
PubMed search

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.^[1][2][3]

References

1. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
2. Katoh M, Katoh M (Aug 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". International Journal of Molecular Medicine 14 (2): 333–8. doi:10.3892/ijmm.14.2.333. PMID 15254788.
3. "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24".

Further reading

• "Toward a complete human genome sequence". Genome Research 8 (11): 1097–108. Nov 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Lee SY, Obata Y, Yoshida M, Stockert E, Williamson B, Jungbluth AA, Chen YT, Old LJ, Scanlan MJ (Mar 2003). "Immunomic analysis of human sarcoma". Proceedings of the National Academy of Sciences of the United States of America 100 (5): 2651–2656. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
• Su ZJ, Hahn CN, Goodall GJ, Reck NM, Leske AF, Davy A, Kremmidiotis G, Vadas MA, Gamble JR (Aug 2004). "A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12212–12217. doi:10.1073/pnas.0404631101. PMC 514459. PMID 15302923.
• Lavelin I, Geiger B (Feb 2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton". The Journal of Biological Chemistry 280 (8): 7178–7185. doi:10.1074/jbc.M411990200. PMID 15611138.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ohta Y, Hartwig JH, Stossel TP (Aug 2006). "FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling". Nature Cell Biology 8 (8): 803–814. doi:10.1038/ncb1437. PMID 16862148.