ARHGAP4

Rho GTPase activating protein 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2EPD​
Identifiers
Symbols	ARHGAP4 ; C1; RGC1; RhoGAP4; SrGAP4; p115
External IDs	OMIM: 300023 MGI: 2159577 HomoloGene: 20403 GeneCards: ARHGAP4 Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • GTPase activator activity • protein binding • Rac GTPase binding Cellular component • nucleoplasm • cytoplasm • cytosol • focal adhesion Biological process • cytoskeleton organization • small GTPase mediated signal transduction • Rho protein signal transduction • positive regulation of signal transduction • negative regulation of cell migration • positive regulation of apoptotic process • positive regulation of GTPase activity • neurotrophin TRK receptor signaling pathway • regulation of small GTPase mediated signal transduction • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	393	171207
Ensembl	ENSG00000089820	ENSMUSG00000031389
UniProt	P98171	Q80Z68
RefSeq (mRNA)	NM_001164741	NM_001162423
RefSeq (protein)	NP_001158213	NP_001155895
Location (UCSC)	Chr X: 153.91 – 153.93 Mb	Chr X: 73.89 – 73.92 Mb
PubMed search

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene.^[1][2] It has been shown to regulate cell motility and axonal outgrowth in vitro.^[3]

References

1. Tribioli C, Droetto S, Bione S, Cesareni G, Torrisi MR, Lotti LV, Lanfrancone L, Toniolo D, Pelicci P (Mar 1996). "An X chromosome-linked gene encoding a protein with characteristics of a rhoGAP predominantly expressed in hematopoietic cells". Proc Natl Acad Sci U S A 93 (2): 695–9. doi:10.1073/pnas.93.2.695. PMC 40115. PMID 8570618.
2. "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4".
3. Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). "ARHGAP4 IS A NOVEL RHOGAP THAT MEDIATES INHIBITION OF CELL MOTILITY AND AXON OUTGROWTH". Molecular and cellular neurosciences 36 (3): 332–42. doi:10.1016/j.mcn.2007.07.004. PMC 2111057. PMID 17804252.

Further reading

• Tribioli C, Mancini M, Plassart E; et al. (1995). "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae". Hum. Mol. Genet. 3 (7): 1061–7. doi:10.1093/hmg/3.7.1061. PMID 7981673.
• Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Brenner V, Nyakatura G, Rosenthal A, Platzer M (1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
• Zuber J, Tchernitsa OI, Hinzmann B; et al. (2000). "A genome-wide survey of RAS transformation targets". Nat. Genet. 24 (2): 144–52. doi:10.1038/72799. PMID 10655059.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Demura M, Takeda Y, Yoneda T; et al. (2002). "Two novel types of contiguous gene deletion of the AVPR2 and ARHGAP4 genes in unrelated Japanese kindreds with nephrogenic diabetes insipidus". Hum. Mutat. 19 (1): 23–9. doi:10.1002/humu.10011. PMID 11754100.
• Christerson LB, Gallagher E, Vanderbilt CA; et al. (2002). "p115 Rho GTPase activating protein interacts with MEKK1". J. Cell. Physiol. 192 (2): 200–8. doi:10.1002/jcp.10125. PMID 12115726.
• Foletta VC, Brown FD, Young WS (2003). "Cloning of rat ARHGAP4/C1, a RhoGAP family member expressed in the nervous system that colocalizes with the Golgi complex and microtubules". Brain Res. Mol. Brain Res. 107 (1): 65–79. doi:10.1016/S0169-328X(02)00448-5. PMID 12414125.
• Soderling SH, Binns KL, Wayman GA; et al. (2003). "The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling". Nat. Cell Biol. 4 (12): 970–5. doi:10.1038/ncb886. PMID 12447388.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains". Int. J. Mol. Med. 11 (6): 791–7. doi:10.3892/ijmm.11.6.791. PMID 12736724.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.