ARHGAP8

Rho GTPase activating protein 8
Identifiers
Symbols	ARHGAP8 ; BPGAP1; PP610
External IDs	OMIM: 609405 MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8 Gene
Gene ontology Molecular function • GTPase activator activity • protein binding Cellular component • cytoplasm • cytosol Biological process • small GTPase mediated signal transduction • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • positive regulation of ERK1 and ERK2 cascade Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23779	73167
Ensembl	ENSG00000241484	ENSMUSG00000078954
UniProt	P85298	Q9CXP4
RefSeq (mRNA)	NM_001017526	NM_001164627
RefSeq (protein)	NP_001017526	NP_001158099
Location (UCSC)	Chr 22: 44.75 – 44.86 Mb	Chr 15: 84.72 – 84.77 Mb
PubMed search

Rho GTPase-activating protein 8 is an protein that in humans is encoded by the ARHGAP8 gene.^[1][2]

Function

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.^[2]

References

1. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208.
2. "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8".

Further reading

• Peck J, Douglas G, Wu CH, Burbelo PD (2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274.
• Shan Z, Haaf T, Popescu NC (2003). "Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8". Gene 303: 55–61. doi:10.1016/S0378-1119(02)01143-5. PMID 12559566.
• Shang X, Zhou YT, Low BC (2003). "Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903–45914. doi:10.1074/jbc.M304514200. PMID 12944407.
• Lua BL, Low BC (2004). "BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migration". Mol. Biol. Cell 15 (6): 2873–2883. doi:10.1091/mbc.E04-02-0141. PMC 420110. PMID 15064355.
• Johnstone CN, Castellví-Bel S, Chang LM, Bessa X, Nakagawa H, Harada H, Sung RK, Piqué JM, Castells A, Rustgi AK (2004). "ARHGAP8 is a novel member of the RHOGAP family related to ARHGAP1/CDC42GAP/p50RHOGAP: mutation and expression analyses in colorectal and breast cancers". Gene 336 (1): 59–71. doi:10.1016/j.gene.2004.01.025. PMID 15225876.
• Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID 15506981.
• Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell. Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID 15944398.