ARHGDIG

Rho GDP dissociation inhibitor (GDI) gamma
Identifiers
Symbols	ARHGDIG ; RHOGDI-3
External IDs	OMIM: 602844 MGI: 108430 HomoloGene: 7337 GeneCards: ARHGDIG Gene
Gene ontology Molecular function • Rho GDP-dissociation inhibitor activity • GTPase activator activity • protein binding Cellular component • cytosol • membrane • cytoplasmic membrane-bounded vesicle Biological process • negative regulation of cell adhesion • small GTPase mediated signal transduction • Rho protein signal transduction • regulation of protein localization • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	398	14570
Ensembl	ENSG00000242173	ENSMUSG00000073433
UniProt	Q99819	Q62160
RefSeq (mRNA)	NM_001176	NM_008113
RefSeq (protein)	NP_001167	NP_032139
Location (UCSC)	Chr 16: 0.27 – 0.28 Mb	Chr 17: 26.2 – 26.21 Mb
PubMed search

Rho GDP-dissociation inhibitor 3 is a protein that in humans is encoded by the ARHGDIG gene.^[1][2][3]

Interactions

ARHGDIG has been shown to interact with RHOB.^[4]

References

1. Adra CN, Manor D, Ko JL, Zhu S, Horiuchi T, Van Aelst L, Cerione RA, Lim B (May 1997). "RhoGDIγ: A GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas". Proc Natl Acad Sci U S A 94 (9): 4279–84. doi:10.1073/pnas.94.9.4279. PMC 20713. PMID 9113980.
2. Brunet N, Morin A, Olofsson B (Apr 2002). "RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain". Traffic 3 (5): 342–57. doi:10.1034/j.1600-0854.2002.30504.x. PMID 11967128.
3. "Entrez Gene: ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma".
4. Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (Nov 1996). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. PMID 8939998.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Zalcman G, Closson V, Camonis J, Honoré N, Rousseau-Merck MF, Tavitian A, Olofsson B (1997). "RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. 271 (48): 30366–74. doi:10.1074/jbc.271.48.30366. PMID 8939998.
• Adra CN, Iyengar AR, Syed FA, Kanaan IN, Rilo HL, Yu W, Kheraj R, Lin SR, Horiuchi T, Khan S, Weremowicz S, Lim B, Morton CC, Higgs DR (1998). "Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3". Genomics 53 (1): 104–9. doi:10.1006/geno.1998.5482. PMID 9787082.
• Elenich LA, Nandi D, Kent AE, McCluskey TS, Cruz M, Iyer MN, Woodward EC, Conn CW, Ochoa AL, Ginsburg DB, Monaco JJ (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics 49 (10): 835–42. doi:10.1007/s002510050562. PMID 10436176.
• Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient and Modulates Activities of Other Rho GTPases by an Inhibitory Function". Mol. Cell. Biol. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807.
• del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA (2004). "Integrins regulate Rac targeting by internalization of membrane domains". Science 303 (5659): 839–42. doi:10.1126/science.1092571. PMID 14764880.
• Dransart E, Morin A, Cherfils J, Olofsson B (2005). "Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors". J. Biol. Chem. 280 (6): 4674–83. doi:10.1074/jbc.M409741200. PMID 15513926.