ARHGEF3

Rho guanine nucleotide exchange factor (GEF) 3
Identifiers
Symbols	ARHGEF3 ; GEF3; STA3; XPLN
External IDs	OMIM: 612115 MGI: 1918954 HomoloGene: 41329 GeneCards: ARHGEF3 Gene
Gene ontology Molecular function • Rho guanyl-nucleotide exchange factor activity • protein binding Cellular component • intracellular • cytosol Biological process • small GTPase mediated signal transduction • Rho protein signal transduction • regulation of Rho protein signal transduction • positive regulation of apoptotic process • positive regulation of GTPase activity • neurotrophin TRK receptor signaling pathway • regulation of small GTPase mediated signal transduction • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50650	71704
Ensembl	ENSG00000163947	ENSMUSG00000021895
UniProt	Q9NR81	Q91X46
RefSeq (mRNA)	NM_001128615	NM_001289686
RefSeq (protein)	NP_001122087	NP_001276615
Location (UCSC)	Chr 3: 56.73 – 57.08 Mb	Chr 14: 27.24 – 27.4 Mb
PubMed search

Rho guanine nucleotide exchange factor (GEF) 3, also known as ARHGEF3, is a human gene.^[1]

Function

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to the NET1A protein.^[1]

Interactions

ARHGEF3 has been shown to interact with RHOA^[2] and RHOB.^[2]

References

1. "Entrez Gene: ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3".
2. Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (Nov 2002). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Thiesen S, Kübart S, Ropers HH, Nothwang HG (2000). "Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22". Biochem. Biophys. Res. Commun. 273 (1): 364–9. doi:10.1006/bbrc.2000.2925. PMID 10873612.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (2003). "XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC". J. Biol. Chem. 277 (45): 42964–72. doi:10.1074/jbc.M207401200. PMID 12221096.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.