ARID4B

AT rich interactive domain 4B (RBP1-like)
Identifiers
Symbols	ARID4B ; BCAA; BRCAA1; RBBP1L1; RBP1L1; SAP180
External IDs	OMIM: 609696 MGI: 2137512 HomoloGene: 12847 GeneCards: ARID4B Gene
Gene ontology Molecular function • molecular_function • protein binding • transcription regulatory region DNA binding Cellular component • cellular_component • nucleus • nucleoplasm • cytoplasm Biological process • chromatin organization • regulation of gene expression by genetic imprinting • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • spermatogenesis • biological_process • gene expression • histone H4-K20 trimethylation • histone H3-K9 trimethylation • regulation of gene expression, epigenetic • negative regulation of gene expression, epigenetic • positive regulation of transcription from RNA polymerase II promoter • establishment of Sertoli cell barrier Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51742	94246
Ensembl	ENSG00000054267	ENSMUSG00000039219
UniProt	Q4LE39	A2CG63
RefSeq (mRNA)	NM_001206794	NM_194262
RefSeq (protein)	NP_001193723	NP_919238
Location (UCSC)	Chr 1: 235.13 – 235.33 Mb	Chr 13: 14.06 – 14.2 Mb
PubMed search

AT-rich interactive domain-containing protein 4B is a protein that in humans is encoded by the ARID4B gene.^[1][2]

Function

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependent SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized.^[2]

References

1. Cao J, Gao T, Stanbridge EJ, Irie R (Aug 2001). "RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis". J Natl Cancer Inst 93 (15): 1159–65. doi:10.1093/jnci/93.15.1159. PMID 11481388.
2. "Entrez Gene: ARID4B AT rich interactive domain 4B (RBP1-like)".

Further reading

• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003). "Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease.". J. Cell Biol. 159 (4): 563–9. doi:10.1083/jcb.200208001. PMC 2173089. PMID 12446740.
• Fleischer TC, Yun UJ, Ayer DE (2003). "Identification and characterization of three new components of the mSin3A corepressor complex.". Mol. Cell. Biol. 23 (10): 3456–67. doi:10.1128/MCB.23.10.3456-3467.2003. PMC 164750. PMID 12724404.
• Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004). "Characterization of BRCAA1 and its novel antigen epitope identification.". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45. PMID 15247124.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.