ARID5B

AT rich interactive domain 5B (MRF1-like)
PDB rendering based on 1ig6.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1IG6​, 2OEH​
Identifiers
Symbols	ARID5B ; DESRT; MRF-2; MRF2
External IDs	OMIM: 608538 MGI: 2175912 HomoloGene: 45872 GeneCards: ARID5B Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription coactivator activity • protein binding • transcription regulatory region DNA binding Cellular component • nucleus • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • kidney development • liver development • chromatin organization • transcription, DNA-templated • male gonad development • female gonad development • post-embryonic development • fibroblast migration • adrenal gland development • multicellular organism growth • fat cell differentiation • negative regulation of transcription, DNA-templated • platelet-derived growth factor receptor signaling pathway • cell development • muscle organ morphogenesis • skeletal system morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • palate development • face morphogenesis • adipose tissue development • fat pad development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84159	71371
Ensembl	ENSG00000150347	ENSMUSG00000019947
UniProt	Q14865	Q8BM75
RefSeq (mRNA)	NM_001244638	NM_023598
RefSeq (protein)	NP_001231567	NP_076087
Location (UCSC)	Chr 10: 61.9 – 62.1 Mb	Chr 10: 68.1 – 68.28 Mb
PubMed search

AT-rich interactive domain-containing protein 5B is a protein that in humans is encoded by the ARID5B gene.^[1][2][3]

Alternative names for this gene include Modulator recognition factor 23.

Genomics

The gene is located on the long arm of chromosome 10 (10q21.2) on the Watson (plus) strand. It spans 195,261 base pairs in length. It encodes a protein of predicted length and molecular weight of 1188 amino acids and 132.375 kilo Daltons respectively.

Clinical importance

This gene has been associated with childhood leukaemia.

References

1. Lahoud MH, Ristevski S, Venter DJ, Jermiin LS, Bertoncello I, Zavarsek S, Hasthorpe S, Drago J, de Kretser D, Hertzog PJ, Kola I (Aug 2001). "Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs". Genome Research 11 (8): 1327–34. doi:10.1101/gr.168801. PMID 11483573.
2. Zhu L, Hu J, Lin D, Whitson R, Itakura K, Chen Y (Aug 2001). "Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA". Biochemistry 40 (31): 9142–50. doi:10.1021/bi010476a. PMID 11478881.
3. "Entrez Gene: ARID5B AT rich interactive domain 5B (MRF1-like)".

Further reading

• Yuan YC, Whitson RH, Liu Q, Itakura K, Chen Y (Nov 1998). "A novel DNA-binding motif shares structural homology to DNA replication and repair nucleases and polymerases". Nature Structural Biology 5 (11): 959–64. doi:10.1038/2934. PMID 9808040.
• Whitson RH, Huang T, Itakura K (May 1999). "The novel Mrf-2 DNA-binding domain recognizes a five-base core sequence through major and minor-groove contacts". Biochemical and Biophysical Research Communications 258 (2): 326–31. doi:10.1006/bbrc.1999.0643. PMID 10329386.
• Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research 33 (1): 66–80. doi:10.1093/nar/gki145. PMC 546134. PMID 15640446.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.