ARIH2

Ariadne RBR E3 ubiquitin protein ligase 2
Identifiers
Symbols	ARIH2 ; ARI2; TRIAD1
External IDs	OMIM: 605615 MGI: 1344361 HomoloGene: 48424 GeneCards: ARIH2 Gene
Gene ontology Molecular function • nucleic acid binding • ubiquitin-protein transferase activity • protein binding • zinc ion binding • ligase activity Cellular component • nucleus • cytoplasm Biological process • protein polyubiquitination • multicellular organismal development • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • developmental cell growth • protein K63-linked ubiquitination • protein K48-linked ubiquitination • hematopoietic stem cell proliferation • positive regulation of protein targeting to mitochondrion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10425	23807
Ensembl	ENSG00000177479	ENSMUSG00000064145
UniProt	O95376	Q9Z1K6
RefSeq (mRNA)	NM_006321	NM_011790
RefSeq (protein)	NP_006312	NP_035920
Location (UCSC)	Chr 3: 48.92 – 48.99 Mb	Chr 9: 108.6 – 108.65 Mb
PubMed search

Protein ariadne-2 homolog is a protein that in humans is encoded by the ARIH2 gene.^[1][2]

References

1. van der Reijden BA, Erpelinck-Verschueren CA, Löwenberg B, Jansen JH (1999). "TRIADs: a new class of proteins with a novel cysteine-rich signature". Protein Sci. 8 (7): 1557–61. doi:10.1110/ps.8.7.1557. PMC 2144383. PMID 10422847.
2. "Entrez Gene: ARIH2 ariadne homolog 2 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Aguilera M, Oliveros M, Martínez-Padrón M, Barbas JA, Ferrús A (2000). "Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins". Genetics 155 (3): 1231–44. PMC 1461160. PMID 10880484.
• Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Wong ES, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY, Guy GR (2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. doi:10.1093/emboj/cdf493. PMC 126289. PMID 12234920.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Marteijn JA, van Emst L, Erpelinck-Verschueren CA, Nikoloski G, Menke A, de Witte T, Löwenberg B, Jansen JH, van der Reijden BA (2005). "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells". Blood 106 (13): 4114–23. doi:10.1182/blood-2005-04-1450. PMID 16118314.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, Jansen JH, Van der Reijden BA (2007). "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1". Blood 110 (9): 3128–35. doi:10.1182/blood-2006-11-058602. PMID 17646546.