ARL4A

ADP-ribosylation factor-like 4A
Identifiers
Symbols	ARL4A ; ARL4
External IDs	OMIM: 604786 MGI: 99437 HomoloGene: 4194 GeneCards: ARL4A Gene
Gene ontology Molecular function • protein binding • GTP binding Cellular component • nucleus • nucleolus • cytoplasm • plasma membrane Biological process • small GTPase mediated signal transduction • brown fat cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10124	11861
Ensembl	ENSG00000122644	ENSMUSG00000047446
UniProt	P40617	P61213
RefSeq (mRNA)	NM_001037164	NM_001039515
RefSeq (protein)	NP_001032241	NP_001034604
Location (UCSC)	Chr 7: 12.69 – 12.69 Mb	Chr 12: 40.01 – 40.04 Mb
PubMed search

ADP-ribosylation factor-like protein 4A is a protein that in humans is encoded by the ARL4A gene.^[1]

Function

ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.^[1]

Interactions

ARL4A has been shown to interact with Karyopherin alpha 2.^[2]

References

1. "Entrez Gene: ARL4A ADP-ribosylation factor-like 4A".
2. Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (December 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, Schürmann A, Joost HG (1999). "ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal.". FEBS Lett. 456 (3): 384–8. doi:10.1016/S0014-5793(99)00759-0. PMID 10462049.
• Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (2001). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli.". J. Biol. Chem. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.
• Hofmann I, Thompson A, Sanderson CM, Munro S (2007). "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.". Curr. Biol. 17 (8): 711–6. doi:10.1016/j.cub.2007.03.007. PMID 17398095.

External links

• ARL4A human gene location in the UCSC Genome Browser.
• ARL4A human gene details in the UCSC Genome Browser.