ARMCX3

Armadillo repeat containing, X-linked 3
Identifiers
Symbols ARMCX3 ; ALEX3; GASP6; dJ545K15.2
External IDs OMIM: 300364 MGI: 1918953 HomoloGene: 9588 GeneCards: ARMCX3 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 51566 71703
Ensembl ENSG00000102401 ENSMUSG00000049047
UniProt Q9UH62 Q8BHS6
RefSeq (mRNA) NM_016607 NM_027870
RefSeq (protein) NP_057691 NP_082146
Location (UCSC) Chr X:
101.62 – 101.63 Mb
Chr X:
134.76 – 134.76 Mb
PubMed search

Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene.[1][2][3][4]

This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.[4]

References

  1. Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas". Biochem Biophys Res Commun 280 (1): 340–7. doi:10.1006/bbrc.2000.4125. PMID 11162520.
  2. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  3. Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally Interacts with the Developmental Regulatory Factor Sox10". J Biol Chem 284 (20): 13629–40. doi:10.1074/jbc.M901177200. PMC 2679464. PMID 19304657.
  4. 1 2 "Entrez Gene: ARMCX3 armadillo repeat containing, X-linked 3".

Further reading


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