ARMET
| Mesencephalic astrocyte-derived neurotrophic factor | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||
| |||||||||||||
| Identifiers | |||||||||||||
| Symbols | MANF ; ARMET; ARP | ||||||||||||
| External IDs | OMIM: 601916 MGI: 1922090 HomoloGene: 4383 GeneCards: MANF Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7873 | 74840 | |||||||||||
| Ensembl | ENSG00000145050 | ENSMUSG00000032575 | |||||||||||
| UniProt | P55145 | Q3TMX5 | |||||||||||
| RefSeq (mRNA) | NM_006010 | NM_029103 | |||||||||||
| RefSeq (protein) | NP_006001 | NP_083379 | |||||||||||
| Location (UCSC) |
Chr 3: 51.39 – 51.39 Mb |
Chr 9: 106.84 – 106.89 Mb | |||||||||||
| PubMed search | |||||||||||||
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein that in humans is encoded by the MANF gene.[1][2]
This gene encodes a highly conserved protein whose function is known. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon.[2]
References
- ↑ Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW (Jun 2003). "MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons". J Mol Neurosci 20 (2): 173–88. doi:10.1385/JMN:20:2:173. PMID 12794311.
- 1 2 "Entrez Gene: ARMET arginine-rich, mutated in early stage tumors".
Further reading
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gevaert K, Goethals M, Martens L; et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Lai MC, Kuo HW, Chang WC, Tarn WY (2003). "A novel splicing regulator shares a nuclear import pathway with SR proteins.". EMBO J. 22 (6): 1359–69. doi:10.1093/emboj/cdg126. PMC 151058. PMID 12628928.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Tanaka H, Shimada Y, Harada H; et al. (2000). "Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients.". Oncol. Rep. 7 (3): 591–3. doi:10.3892/or.7.3.591. PMID 10767373.
- Shridhar V, Rivard S, Wang X; et al. (1997). "Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer.". Oncogene 14 (18): 2213–6. doi:10.1038/sj.onc.1201054. PMID 9174057.
- Shridhar R, Shridhar V, Rivard S; et al. (1997). "Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck.". Cancer Res. 56 (24): 5576–8. PMID 8971156.
- Shridhar V, Rivard S, Shridhar R; et al. (1996). "A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas.". Oncogene 12 (9): 1931–9. PMID 8649854.
This article is issued from Wikipedia - version of the Wednesday, April 29, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.