ARNT2

Aryl-hydrocarbon receptor nuclear translocator 2
Identifiers
Symbols	ARNT2 ; WEDAS; bHLHe1
External IDs	OMIM: 606036 MGI: 107188 HomoloGene: 7230 GeneCards: ARNT2 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • aryl hydrocarbon receptor binding • protein heterodimerization activity Cellular component • nucleus • transcription factor complex • cytoplasm Biological process • response to hypoxia • in utero embryonic development • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • central nervous system development • brain development • positive regulation of cell proliferation • response to estradiol • negative regulation of apoptotic process • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9915	11864
Ensembl	ENSG00000172379	ENSMUSG00000015709
UniProt	Q9HBZ2	Q61324
RefSeq (mRNA)	NM_014862	NM_007488
RefSeq (protein)	NP_055677	NP_031514
Location (UCSC)	Chr 15: 80.4 – 80.6 Mb	Chr 7: 84.25 – 84.41 Mb
PubMed search

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.^[1][2]

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.^[2]

References

1. Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (Mar 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis". Genomics 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670.
2. "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2".

Further reading

• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Moffett P, Pelletier J (2000). "Different transcriptional properties of mSim-1 and mSim-2.". FEBS Lett. 466 (1): 80–6. doi:10.1016/S0014-5793(99)01750-0. PMID 10648817.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Barrow LL, Wines ME, Romitti PA; et al. (2003). "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts.". Teratology 66 (2): 85–90. doi:10.1002/tera.10062. PMID 12210012.
• Stolze I, Berchner-Pfannschmidt U, Freitag P; et al. (2002). "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells.". Blood 100 (7): 2623–8. doi:10.1182/blood-2001-12-0169. PMID 12239177.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ooe N, Saito K, Mikami N; et al. (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/MCB.24.2.608-616.2004. PMC 343817. PMID 14701734.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Friedman ER, Fan CM (2007). "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription.". Biochem. Biophys. Res. Commun. 363 (1): 113–8. doi:10.1016/j.bbrc.2007.08.108. PMC 2083645. PMID 17826745.