ARPC1A

Actin related protein 2/3 complex, subunit 1A, 41kDa
Identifiers
Symbols	ARPC1A ; Arc40; HEL-68; SOP2Hs; SOP2L
External IDs	OMIM: 604220 MGI: 1928896 HomoloGene: 4675 GeneCards: ARPC1A Gene
Gene ontology Molecular function • actin binding • actin filament binding Cellular component • cytosol • Arp2/3 protein complex • actin cytoskeleton • extracellular exosome Biological process • small GTPase mediated signal transduction • axon guidance • actin cytoskeleton organization • Arp2/3 complex-mediated actin nucleation • Fc-gamma receptor signaling pathway involved in phagocytosis • innate immune response • ephrin receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10552	56443
Ensembl	ENSG00000241685	ENSMUSG00000029621
UniProt	Q92747	Q9R0Q6
RefSeq (mRNA)	NM_001190996	NM_019767
RefSeq (protein)	NP_001177925	NP_062741
Location (UCSC)	Chr 7: 99.33 – 99.39 Mb	Chr 5: 145.08 – 145.11 Mb
PubMed search

Actin-related protein 2/3 complex subunit 1A is a protein that in humans is encoded by the ARPC1A gene.^[1][2][3]

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages.^[3]

References

1. Balasubramanian MK, Feoktistova A, McCollum D, Gould KL (Jan 1997). "Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function". EMBO J 15 (23): 6426–37. PMC 452468. PMID 8978670.
2. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (Aug 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J Cell Biol 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
3. "Entrez Gene: ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Machesky LM, Reeves E, Wientjes F; et al. (1998). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 (1): 105–12. PMC 1218893. PMID 9359840.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA; et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.