ARPP-19

CAMP-regulated phosphoprotein, 19kDa
Identifiers
Symbols	ARPP19 ; ARPP-16; ARPP-19; ARPP16; ENSAL
External IDs	OMIM: 605487 MGI: 1891691 HomoloGene: 21318 GeneCards: ARPP19 Gene
Gene ontology Molecular function • protein phosphatase inhibitor activity • receptor binding • protein phosphatase type 2A regulator activity • potassium channel regulator activity • phosphatase inhibitor activity • protein phosphatase 2A binding Cellular component • nucleoplasm • cytoplasm Biological process • G2/M transition of mitotic cell cycle • mitotic cell cycle • mitotic nuclear division • dopamine receptor signaling pathway • regulation of protein phosphatase type 2A activity • negative regulation of catalytic activity • positive regulation of gluconeogenesis • positive regulation of glucose import • positive regulation of Ras protein signal transduction • cell division Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10776	59046
Ensembl	ENSG00000128989	ENSMUSG00000007656
UniProt	P56211	P56212
RefSeq (mRNA)	NM_001306191	NM_001142655
RefSeq (protein)	NP_001293120	NP_001136127
Location (UCSC)	Chr 15: 52.55 – 52.57 Mb	Chr 9: 75.04 – 75.06 Mb
PubMed search

cAMP-regulated phosphoprotein 19 is a protein that in humans is encoded by the ARPP19 gene.^[1][2][3]

References

1. Dulubova I, Horiuchi A, Snyder GL, Girault JA, Czernik AJ, Shao L, Ramabhadran R, Greengard P, Nairn AC (2001). "ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins". J. Neurochem. 77 (1): 229–38. doi:10.1046/j.1471-4159.2001.t01-1-00191.x. PMID 11279279.
2. Peyrollier K, Héron L, Virsolvy-Vergine A, Le Cam A, Bataille D (1996). "Alpha endosulfine is a novel molecule, structurally related to a family of phosphoproteins". Biochem. Biophys. Res. Commun. 223 (3): 583–6. doi:10.1006/bbrc.1996.0938. PMID 8687439.
3. "Entrez Gene: ARPP-19 cyclic AMP phosphoprotein, 19 kD".

Further reading

• Kim SH, Nairn AC, Cairns N, Lubec G (2001). "Decreased levels of ARPP-19 and PKA in brains of Down syndrome and Alzheimer's disease". J. Neural Transm. Suppl. (61): 263–72. doi:10.1007/978-3-7091-6262-0_21. PMID 11771749.
• Chin LS, Singh SK, Wang Q, Murray SF (2000). "Identification of okadaic-acid-induced genes by mRNA differential display in glioma cells". J. Biomed. Sci. 7 (2): 152–9. doi:10.1007/BF02256622. PMID 10754390.
• Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (1998). "Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8387–91. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
• Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. PMID 8120638.
• Horiuchi A, Williams KR, Kurihara T, Nairn AC, Greengard P (1990). "Purification and cDNA cloning of ARPP-16, a cAMP-regulated phosphoprotein enriched in basal ganglia, and of a related phosphoprotein, ARPP-19". J. Biol. Chem. 265 (16): 9476–84. PMID 2160982.