ASAH2
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.[1][2]
References
- ↑ El Bawab S, Roddy P, Qian T, Bielawska A, Lemasters JJ, Hannun YA (Aug 2000). "Molecular cloning and characterization of a human mitochondrial ceramidase". J Biol Chem 275 (28): 21508–13. doi:10.1074/jbc.M002522200. PMID 10781606.
- ↑ "Entrez Gene: ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2".
Further reading
- Matoba R, Okubo K, Hori N; et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
- Tani M, Okino N, Mori K; et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases.". J. Biol. Chem. 275 (15): 11229–34. doi:10.1074/jbc.275.15.11229. PMID 10753931.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Choi MS, Anderson MA, Zhang Z; et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis.". Gene 315: 113–22. doi:10.1016/S0378-1119(03)00721-2. PMID 14557071.
- Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Monick MM, Mallampalli RK, Bradford M; et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.". J. Immunol. 173 (1): 123–35. doi:10.4049/jimmunol.173.1.123. PMID 15210766.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hwang YH, Tani M, Nakagawa T; et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells.". Biochem. Biophys. Res. Commun. 331 (1): 37–42. doi:10.1016/j.bbrc.2005.03.134. PMID 15845354.
- Osawa Y, Uchinami H, Bielawski J; et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha.". J. Biol. Chem. 280 (30): 27879–87. doi:10.1074/jbc.M503002200. PMID 15946935.
- Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets.". J. Lipid Res. 46 (11): 2458–67. doi:10.1194/jlr.M500268-JLR200. PMID 16061940.
- Galadari S, Wu BX, Mao C; et al. (2006). "Identification of a novel amidase motif in neutral ceramidase.". Biochem. J. 393 (Pt 3): 687–95. doi:10.1042/BJ20050682. PMC 1360721. PMID 16229686.
- Xu R, Jin J, Hu W; et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.". FASEB J. 20 (11): 1813–25. doi:10.1096/fj.05-5689com. PMID 16940153.
- Avramopoulos D, Wang R, Valle D; et al. (2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.". Neurogenetics 8 (2): 111–20. doi:10.1007/s10048-007-0081-5. PMID 17334805.
- Ohlsson L, Palmberg C, Duan RD; et al. (2007). "Purification and characterization of human intestinal neutral ceramidase.". Biochimie 89 (8): 950–60. doi:10.1016/j.biochi.2007.03.009. PMID 17475390.
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