ASB13
| Ankyrin repeat and SOCS box containing 13 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ASB13 ; FLJ13134; MGC19879 | ||||||||||||
| External IDs | OMIM: 615055 MGI: 2145525 HomoloGene: 11666 GeneCards: ASB13 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 79754 | 142688 | |||||||||||
| Ensembl | ENSG00000196372 | ENSMUSG00000033781 | |||||||||||
| UniProt | Q8WXK3 | Q8VBX0 | |||||||||||
| RefSeq (mRNA) | NM_024701 | NM_001267724 | |||||||||||
| RefSeq (protein) | NP_078977 | NP_001254653 | |||||||||||
| Location (UCSC) |
Chr 10: 5.64 – 5.67 Mb |
Chr 13: 3.63 – 3.65 Mb | |||||||||||
| PubMed search | |||||||||||||
Ankyrin repeat and SOCS box protein 13 is a protein that in humans is encoded by the ASB13 gene.[1][2]
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length sequences are not known.[2]
References
- ↑ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- 1 2 "Entrez Gene: ASB13 ankyrin repeat and SOCS box-containing 13".
Further reading
- Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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