ASB2

Ankyrin repeat and SOCS box containing 2
Identifiers
Symbols	ASB2 ; ASB-2
External IDs	OMIM: 605759 MGI: 1929743 HomoloGene: 69202 GeneCards: ASB2 Gene
Gene ontology Molecular function • protein binding • ubiquitin protein ligase activity Cellular component • Cul5-RING ubiquitin ligase complex Biological process • protein polyubiquitination • positive regulation of defense response to virus by host • signal transduction • intracellular signal transduction • skeletal muscle cell differentiation • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • myoblast differentiation • activation of mitophagy in response to mitochondrial depolarization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51676	65256
Ensembl	ENSG00000100628	ENSMUSG00000021200
UniProt	Q96Q27	Q8K0L0
RefSeq (mRNA)	NM_001202429	NM_023049
RefSeq (protein)	NP_001189358	NP_075536
Location (UCSC)	Chr 14: 93.93 – 93.98 Mb	Chr 12: 103.32 – 103.36 Mb
PubMed search

Ankyrin repeat and SOCS box protein 2 is a protein that in humans is encoded by the ASB2 gene.^[1]

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. This gene is induced by all-trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.^[1]

References

1. "Entrez Gene: ASB2 ankyrin repeat and SOCS box-containing 2".

Further reading

• Kile BT, Schulman BA, Alexander WS; et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Hilton DJ, Richardson RT, Alexander WS; et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMC 18144. PMID 9419338.
• Kile BT, Viney EM, Willson TA; et al. (2001). "Cloning and characterization of the genes encoding the ankyrin repeat and SOCS box-containing proteins Asb-1, Asb-2, Asb-3 and Asb-4.". Gene 258 (1–2): 31–41. doi:10.1016/S0378-1119(00)00402-9. PMID 11111040.
• Kile BT, Metcalf D, Mifsud S; et al. (2001). "Functional analysis of Asb-1 using genetic modification in mice". Mol. Cell. Biol. 21 (18): 6189–97. doi:10.1128/MCB.21.18.6189-6197.2001. PMC 87336. PMID 11509662.
• Kohroki J, Fujita S, Itoh N; et al. (2001). "ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells". FEBS Lett. 505 (2): 223–8. doi:10.1016/S0014-5793(01)02829-0. PMID 11566180.
• Guibal FC, Moog-Lutz C, Smolewski P; et al. (2002). "ASB-2 inhibits growth and promotes commitment in myeloid leukemia cells". J. Biol. Chem. 277 (1): 218–24. doi:10.1074/jbc.M108476200. PMID 11682484.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Namciu SJ, Friedman RD, Marsden MD; et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
• Colland F, Jacq X, Trouplin V; et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Heuzé ML, Guibal FC, Banks CA; et al. (2005). "ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex". J. Biol. Chem. 280 (7): 5468–74. doi:10.1074/jbc.M413040200. PMID 15590664.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kohroki J, Nishiyama T, Nakamura T, Masuho Y (2006). "ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes". FEBS Lett. 579 (30): 6796–802. doi:10.1016/j.febslet.2005.11.016. PMID 16325183.