Asporin
| Asporin | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ASPN ; OS3; PLAP-1; PLAP1; SLRR1C | ||||||||||||
| External IDs | OMIM: 608135 MGI: 1913945 HomoloGene: 32357 GeneCards: ASPN Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 54829 | 66695 | |||||||||||
| Ensembl | ENSG00000106819 | ENSMUSG00000021388 | |||||||||||
| UniProt | Q9BXN1 | Q99MQ4 | |||||||||||
| RefSeq (mRNA) | NM_001193335 | NM_001172481 | |||||||||||
| RefSeq (protein) | NP_001180264 | NP_001165952 | |||||||||||
| Location (UCSC) |
Chr 9: 92.46 – 92.48 Mb |
Chr 13: 49.54 – 49.57 Mb | |||||||||||
| PubMed search | |||||||||||||
Asporin is a protein that in humans is encoded by the ASPN gene.[1]
Function
ASPN belongs to a family of leucine-rich repeat (LRR) proteins associated with the cartilage matrix. The name asporin reflects the unique aspartate-rich N terminus and the overall similarity to decorin (MIM 125255) (Lorenzo et al., 2001).[1]
References
Further reading
- Lorenzo P, Aspberg A, Onnerfjord P, Bayliss MT, Neame PJ, Heinegard D (Apr 2001). "Identification and characterization of asporin. a novel member of the leucine-rich repeat protein family closely related to decorin and biglycan". The Journal of Biological Chemistry 276 (15): 12201–11. doi:10.1074/jbc.M010932200. PMID 11152692.
- Henry SP, Takanosu M, Boyd TC, Mayne PM, Eberspaecher H, Zhou W, de Crombrugghe B, Hook M, Mayne R (Apr 2001). "Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family". The Journal of Biological Chemistry 276 (15): 12212–21. doi:10.1074/jbc.M011290200. PMID 11152695.
- Yamada S, Murakami S, Matoba R, Ozawa Y, Yokokoji T, Nakahira Y, Ikezawa K, Takayama S, Matsubara K, Okada H (Sep 2001). "Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene". Gene 275 (2): 279–86. doi:10.1016/S0378-1119(01)00683-7. PMID 11587855.
- Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, Mabuchi A, Kotani A, Kawakami A, Yamamoto S, Uchida A, Nakamura K, Notoya K, Nakamura Y, Ikegawa S (Feb 2005). "An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis". Nature Genetics 37 (2): 138–44. doi:10.1038/ng1496. PMID 15640800.
- Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A (2006). "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians". Arthritis Research & Therapy 8 (3): R55. doi:10.1186/ar1920. PMC 1526645. PMID 16542493.
- Yamada S, Ozawa Y, Tomoeda M, Matoba R, Matsubara K, Murakami S (May 2006). "Regulation of PLAP-1 expression in periodontal ligament cells". Journal of Dental Research 85 (5): 447–51. doi:10.1177/154405910608500510. PMID 16632759.
- Jiang Q, Shi D, Yi L, Ikegawa S, Wang Y, Nakamura T, Qiao D, Liu C, Dai J (2007). "Replication of the association of the aspartic acid repeat polymorphism in the asporin gene with knee-osteoarthritis susceptibility in Han Chinese". Journal of Human Genetics 51 (12): 1068–72. doi:10.1007/s10038-006-0065-6. PMID 17024313.
- Nakamura T, Shi D, Tzetis M, Rodriguez-Lopez J, Miyamoto Y, Tsezou A, Gonzalez A, Jiang Q, Kamatani N, Loughlin J, Ikegawa S (Jul 2007). "Meta-analysis of association between the ASPN D-repeat and osteoarthritis". Human Molecular Genetics 16 (14): 1676–81. doi:10.1093/hmg/ddm115. PMID 17517696.
- Shi D, Nakamura T, Dai J, Yi L, Qin J, Chen D, Xu Z, Wang Y, Ikegawa S, Jiang Q (2007). "Association of the aspartic acid-repeat polymorphism in the asporin gene with age at onset of knee osteoarthritis in Han Chinese population". Journal of Human Genetics 52 (8): 664–7. doi:10.1007/s10038-007-0166-x. PMID 17603749.
- Kou I, Nakajima M, Ikegawa S (Nov 2007). "Expression and regulation of the osteoarthritis-associated protein asporin". The Journal of Biological Chemistry 282 (44): 32193–9. doi:10.1074/jbc.M706262200. PMID 17804408.
- Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S (Nov 2007). "Mechanisms for asporin function and regulation in articular cartilage". The Journal of Biological Chemistry 282 (44): 32185–92. doi:10.1074/jbc.M700522200. PMID 17827158.
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