ASTL

Astacin-like metallo-endopeptidase (M12 family)
Identifiers
Symbols	ASTL ; SAS1B
External IDs	OMIM: 608860 HomoloGene: 128191 GeneCards: ASTL Gene
EC number	3.4.24.21
Gene ontology Molecular function • metalloendopeptidase activity • peptidase activity • zinc ion binding • aspartic-type peptidase activity • glutamic-type peptidase activity Cellular component • cytoplasm • plasma membrane • transport vesicle • cortical granule Biological process • proteolysis • cell adhesion • fertilization • positive regulation of protein processing • prevention of polyspermy • negative regulation of binding of sperm to zona pellucida Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	431705	215095
Ensembl	ENSG00000188886	ENSMUSG00000050468
UniProt	Q6HA08	Q6HA09
RefSeq (mRNA)	NM_001002036	NM_001291003
RefSeq (protein)	NP_001002036	NP_001277932
Location (UCSC)	Chr 2: 96.12 – 96.14 Mb	Chr 2: 127.34 – 127.36 Mb
PubMed search

Astacin-like metallo-endopeptidase (M12 family) is a protein that in humans is encoded by the ASTL gene.^[1][2]

References

1. "Entrez Gene: Astacin-like metallo-endopeptidase (M12 family)".
2. Quesada V, Sánchez LM, Alvarez J, López-Otín C (2004). "Identification and characterization of human and mouse ovastacin: a novel metalloproteinase similar to hatching enzymes from arthropods, birds, amphibians, and fish". J. Biol. Chem. 279 (25): 26627–34. doi:10.1074/jbc.M401588200. PMID 15087446.