ATG7

Autophagy related 7
Identifiers
Symbols	ATG7 ; APG7-LIKE; APG7L; GSA7
External IDs	OMIM: 608760 MGI: 1921494 HomoloGene: 4662 GeneCards: ATG7 Gene
Gene ontology Molecular function • ubiquitin activating enzyme activity • protein binding • transcription factor binding • Atg12 activating enzyme activity • Atg8 activating enzyme activity • protein homodimerization activity Cellular component • pre-autophagosomal structure • cytoplasm • cytosol • axoneme Biological process • mitophagy • liver development • cellular protein modification process • protein lipidation • C-terminal protein lipidation • cellular amino acid metabolic process • cellular response to nitrogen starvation • adult walking behavior • cellular response to starvation • post-embryonic development • positive regulation of autophagy • protein transport • macroautophagy • positive regulation of macroautophagy • protein ubiquitination • cerebellar Purkinje cell layer development • pyramidal neuron development • central nervous system neuron axonogenesis • cerebral cortex development • protein catabolic process • regulation of protein ubiquitination • positive regulation of protein modification process • protein modification by small protein conjugation • piecemeal microautophagy of nucleus • suppression by virus of host autophagy • negative stranded viral RNA replication • positive regulation of apoptotic process • negative regulation of apoptotic process • late nucleophagy • positive regulation of protein catabolic process • neurological system process • defense response to virus • cardiac muscle cell development • membrane fusion • positive regulation of mucus secretion • cellular response to hyperoxia • regulation of mitophagy • negative regulation of histone H4-K16 acetylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10533	74244
Ensembl	ENSG00000197548	ENSMUSG00000030314
UniProt	O95352	Q9D906
RefSeq (mRNA)	NM_001136031	NM_001253717
RefSeq (protein)	NP_001129503	NP_001240646
Location (UCSC)	Chr 3: 11.27 – 11.56 Mb	Chr 6: 114.64 – 114.86 Mb
PubMed search

Autophagy-related protein 7 is a protein that in humans is encoded by the ATG7 gene.^[1][2]

This gene was identified based on homology to Pichia pastoris GSA7 and Saccharomyces cerevisiae APG7. In the yeast, the protein appears to be required for fusion of peroxisomal and vaculuolar membranes. The protein shows homology to the ATP-binding and catalytic sites of the E1 ubiquitin activating enzymes.^[2]

References

1. Yuan W, Stromhaug PE, Dunn WA Jr (Jun 1999). "Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein". Mol Biol Cell 10 (5): 1353–66. doi:10.1091/mbc.10.5.1353. PMC 25277. PMID 10233149.
2. "Entrez Gene: ATG7 ATG7 autophagy related 7 homolog (S. cerevisiae)".

Further reading

• Tanida I, Tanida-Miyake E, Komatsu M; et al. (2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.". J. Biol. Chem. 277 (16): 13739–44. doi:10.1074/jbc.M200385200. PMID 11825910.
• Tanida I, Tanida-Miyake E, Nishitani T; et al. (2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.". Biochem. Biophys. Res. Commun. 292 (1): 256–62. doi:10.1006/bbrc.2002.6645. PMID 11890701.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mizushima N, Yoshimori T, Ohsumi Y (2003). "Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.". FEBS Lett. 532 (3): 450–4. doi:10.1016/S0014-5793(02)03739-0. PMID 12482611.
• Nemoto T, Tanida I, Tanida-Miyake E; et al. (2003). "The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.". J. Biol. Chem. 278 (41): 39517–26. doi:10.1074/jbc.C200334200. PMID 12890687.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T; et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Tanida I, Sou YS, Minematsu-Ikeguchi N; et al. (2006). "Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3.". FEBS J. 273 (11): 2553–62. doi:10.1111/j.1742-4658.2006.05260.x. PMID 16704426.