ATP10 protein

ATP10 protein
Identifiers
Symbol	ATP-synt_10
Pfam	PF05176
InterPro	IPR007849
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, ATP10 protein (mitochondrial ATPase complex subunit ATP10) is an ATP synthase assembly factor. It is essential for the assembly of the mitochondrial F₁-F₀ complex. A yeast nuclear gene (ATP10) encodes a product that is essential for the assembly of a functional mitochondrial ATPase complex. Mutations in ATP10 induce a loss of rutamycin sensitivity in the mitochondrial ATPase, but do not affect the respiratory enzymes. ATP10 has a molecular weight of 30,293 Da and its primary structure is not related to any known subunit of the yeast or mammalian mitochondrial ATPase complexes. ATP10 is associated with the mitochondrial membrane. It is suggested that the ATP10 product is not a subunit of the ATPase complex but rather a protein required for the assembly of the F₀ sector of the complex.^[1]

References

1. Ackerman SH, Tzagoloff A (June 1990). "ATP10, a yeast nuclear gene required for the assembly of the mitochondrial F₁-F₀ complex". J. Biol. Chem. 265 (17): 9952–9. PMID 2141026.

This article incorporates text from the public domain Pfam and InterPro IPR007849